Citation: TANG Ming-Qing, MAO Xu-Hua, GONG Yi-Xin-Yue, QING Lin-Sen, XIE Jing. Research Progress of C-reactive Protein Analysis[J]. Chinese Journal of Analytical Chemistry, ;2020, 48(9): 1121-1130. doi: 10.19756/j.issn.0253-3820.201111 shu

Research Progress of C-reactive Protein Analysis

1.
School of Pharmacy, Chengdu Medical College, Chengdu 610500, China;
2.
Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China;
3.
Department of Clinical Laboratory, The Affiliated Yixing Hospital of Jiangsu University, Yixing 214200, China

Received Date: 5 March 2020
Revised Date: 6 July 2020

Fund Project: This work was supported by the CAS "Light of West China" Program (No. 2018XBZG_XBQNXZ_A_005), the Sichuan Science and Technology Program, China (Nos. 2019YFS0112, 2020YJ0132) and the Innovation Training Program for College Students in Sichuan Province (No. S201913705133).

C-reactive protein (CRP) is an important biomarker for acute inflammation and infection, and is widely used clinically for the assessment of various diseases and the monitoring of patients' conditions. At present, the clinical test methods for CRP mainly include immunoturbidimetry, enzyme-linked immunosorbent assays, and lateral flow assays. In recent years, the developments in analysis theory and improvements in materials science have resulted in the continual emergence of analytical methods and techniques, such as biosensor technology and microfluidics. Here, we summarized the development and application of CRP analytical methods and focused on the developments during the last five years. In addition, we predicted the research directions for novel CRP assays and provided new ideas for the development of CRP analytical methods with high sensitivity and specificity that could meet clinical needs.
- C-reactive protein,
- Diagnostics,
- Immunoassay,
- Biosensor,
- Microfluidics,
- Point of care testing,
- Review
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