Citation: WANG Zi-Jian, CHEN Er-Ning, YANG Ge, ZHAO Xin-Ying, QU Feng. Research Advances of Aptamers Selection for Small Molecule Targets[J]. Chinese Journal of Analytical Chemistry, ;2020, 48(5): 573-582. doi: 10.19756/j.issn.0253-3820.201101 shu

Research Advances of Aptamers Selection for Small Molecule Targets

1.
School of Life Science, Beijing Institute of Technology, Key Laboratory of Molecular Medicine and Biological Diagnosis, Ministry of Industry and Information Technology, Beijing 100081, China;
2.
Beijing Center for Physical and Chemical Analysis, Beijing 100089, China

Received Date: 28 February 2020
Revised Date: 20 April 2020

Fund Project: This work was supported by the National Natural Science Foundation of China (Nos. 21675012, 21874010, 21827810).

Aptamer, as a novel recognition molecule, shows great potential in small molecule sensing analysis and detection. Selection of aptamers for small molecules is a pre-requisite for their application. This paper summarizes nearly 100 aptamers which are sequenced against 80 kinds of small molecular targets (e.g. toxins, antibiotics and hormones) from 2015 to 2019. Their equilibrium dissociation constants (K_D) and determination methods are also summarized. In addition, the development and enhancements of systematic evolution of ligands by exponential enrichment (SELEX) methods based on graphene oxide, human genome, quartz crystal microbalance and in silico are briefly introduced.
- Aptamer,
- Small molecule,
- Systematic evolution of ligands by exponential enrichment,
- Review
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1.
沈阳化工大学材料科学与工程学院沈阳 110142