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Citation: LI Meng-Xuan, YIN Ting, XIAO Zun-Hong, NI Xin-Long. Cucurbit[10]uril Host-Guest Based Ratiometric Fluorescent Probe for Recognition of Nilotinib[J]. Chinese Journal of Analytical Chemistry, ;2020, 48(12): 1681-1686. doi: 10.19756/j.issn.0253-3820.201084 shu

Cucurbit[10]uril Host-Guest Based Ratiometric Fluorescent Probe for Recognition of Nilotinib

1.
Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Guizhou University, Guiyang 550025, China;
2.
School of Chemistry and Materials, Guizhou Normal University, Guiyang 550025, China

Received Date: 18 February 2020
Revised Date: 28 September 2020

Fund Project: This work was supported by the National Natural Science Foundation of China (No.21871063) and the Guizhou University (Nos.20175788, 20185781).

Host-guest interaction of cucurbit[10]uril (Q[10] or CB[10]) with pyrene-derived derivatives was evaluated by fluorescence emission spectra and UV-vis absorption spectra, and the host-guest binding modes were studied by density functional theory (DFT). In the energy minimization structures, the pyrene group of the guest was encapsulated in the larger hydrophobic cavity of Q[10] in parallel from the opposite direction in the form of a head-to-head fashion, forming a 2∶1 inclusion. The thermodynamic data indicated that the two host-guest interactions were enthalpy-driven. Furthermore, the Q[10] host-guest interaction of Q[10]/G2 could be used as ratiometric fluorescent probe based on the unique monomer/excimer emission of pyrene moiety on the guest G2. Experiment results indicated that the host-guest interaction derived probe had good recognition and selectivity for nilotinib in aqueous solution, and the detection limit was 7.05 μmol/L.
- Cucurbit[10]uril,
- Pyrene-based derivatives,
- Host-guest interaction,
- Nilotinib,
- Fluorescent probe
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