Citation: CHAO Jing-Bo, WANG Jing-Ru, ZHANG Jing-Qi. Accurate Determination and Characterization of Gold Nanoparticles Based on Single Particle-Inductively Coupled Plasma-Mass Spectrometry[J]. Chinese Journal of Analytical Chemistry, ;2020, 48(7): 946-954. doi: 10.19756/j.issn.0253-3820.191740 shu

Accurate Determination and Characterization of Gold Nanoparticles Based on Single Particle-Inductively Coupled Plasma-Mass Spectrometry

1.
Division of Chemical Metrology and Analytical Science, National Institute of Metrology, Beijing 100029, China;
2.
Chemical Engineering School, Beijing University of Chemical Technology, Beijing 100029, China

Received Date: 14 December 2019
Revised Date: 8 May 2020

Fund Project: This work was supported by the National Key Research and Development Project of China (No.2017YFF0205801) and the NIM Fundamental Research Program (No. 21-AKYS1609).

An accurate determination method for gold nanoparticle number concentration and size was developed based on single particle-inductively coupled plasma-mass spectrometry (SP-ICP-MS). Influence factors such as different calculation methods of transport efficiency, dwell time, dispersing agent and injection mode were investigated and optimized. The transport efficiency had a great impact on the accuracy of the measurement result, and it should be selected according to the measured target parameters. It was important to keep the stability of the transport efficiency and used the calibration standard calibrating during the measurement process. Dwell time directly affected the precision of result, and the data processing mode should be selected carefully according to the sample type, particle size and other properties. When the dwell time was 0.1 ms, for 30 nm and 60 nm gold nanoparticles, the linear ranges were 2-40 pg/g and 10-200 pg/g, respectively, the linear correlation coefficients were greater than 0.9998. The relative standard deviation of particle number concentration was less than 3.80%. The detection limits of particle number concentration and particle size were 110 NPs/g and 9 nm, respectively. Four kinds of synthesized gold nanoparticles and CCQM-P194 international pilot study sample were determined by the established method. The diviation of number concentration in pilot study from the reference values of the key comparison was less than 5%. The results were equivalent and the expanded uncertainty was less than 15% (k=2), which further verified the accuracy and applicability of the method.
- Particle number concentration,
- Particle size,
- Gold nanoparticles,
- Single particle inductively coupled plasma mass spectrometry
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沈阳化工大学材料科学与工程学院沈阳 110142