Citation: SANG Sheng-Bo, GUO Xing, ZHANG Yi-Xia, GUO Jin-Yu, LI Hong-Mei, LI Yan-Ping, ZHANG Qiang, WANG Tao. A Wireless Magnetoelastic Aptasensor for Detection of Carcinoembryonic Antigen[J]. Chinese Journal of Analytical Chemistry, ;2021, 49(5): 718-725. doi: 10.19756/j.issn.0253-3820.191695 shu

A Wireless Magnetoelastic Aptasensor for Detection of Carcinoembryonic Antigen

SANG Sheng-Bo ¹ ,
GUO Xing ^1,, ,
ZHANG Yi-Xia ^1,2 ,
GUO Jin-Yu ¹ ,
LI Hong-Mei ¹ ,
LI Yan-Ping ¹ ,
ZHANG Qiang ¹ ,
WANG Tao ³

1.
MicroNano System Research Center, Key Lab of Advanced Transducers and Intelligent Control System of the Ministry of Education, College of Information and Computer, Taiyuan University of Technology, Jinzhong 030600, China;
2.
Institute of Applied Mechanics & National Demonstration Center for Experimental Mechanics Education, College of Mechanical and Vehicle Engineering, Taiyuan University of Technology, Jinzhong 030600, China;
3.
Shanxi Academy of Medical Sciences & Shanxi Bethune Hospital, Taiyuan 030032, China

Corresponding author: GUO Xing, guo_xing163@163.com
Received Date: 25 November 2019
Revised Date: 3 September 2020

Fund Project: Supported by the National Natural Science Foundation of China (Nos.51705354, 61703298, 81602506, 51975400) and the Science and Technology Innovation Project of Colleges and Universities in Shanxi Province (No.2020L0076).

A novel magnetoelastic (ME) aptasensor containing aptamer functionalized gold-coated ME chip was developed for carcinoembryonic antigen (CEA) detection. Due to its magnetostrictive properties, the signals could be wirelessly detected through magnetic field, which made it potentially suitable for in vivo analysis. The conjugation of aptamers and CEA was successfully confirmed by scanning electron microscopy, atomic force microscopy and energy dispersive spectroscopy. With the optimum modification concentration of CEA-Apt, the ME aptasensor demonstrated a linear range from 1 ng/mL to 100 ng/mL towards CEA concentration with a detection limit (LOD) of 0.09 ng/mL. Clinical chemiluminescence assay (CA method) was carried out to certify the feasibility of the ME aptasensor. The ME aptasensor exhibited excellent selectivity, stability and repeatability towards CEA, which provided a promising method for clinical diagnosis of cancer.
- Aptamer,
- Carcinoembryonic antigen,
- Wireless detection,
- Magnetoelastic aptasensor
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