Citation: ZHAN Fang-Ling, GAO Si-Yu, XIE Yuan-Dong, ZHANG Jin-Ming, LI Yi, LIU Ning. Applications of Click Chemistry Reaction for Proteomics Analysis[J]. Chinese Journal of Analytical Chemistry, ;2020, 48(4): 431-438. doi: 10.19756/j.issn.0253-3820.191674 shu

Applications of Click Chemistry Reaction for Proteomics Analysis

1.
Central Laboratory, the Second Hospital of Jilin University, Changchun 130041, China;
2.
Stomatological Hospital of Jilin University, Changchun 130022, China;
3.
Key Laboratory of Zoonosis Research, Ministry of Education, Jilin University, Changchun 130061, China

Received Date: 15 November 2019
Revised Date: 24 December 2019

Fund Project: This work was supported by the National Nature Science Foundation of China (No. 81472030), the Jilin Province Science and Technology Department Project (No. 20180101267JC) and the Graduate Innovation Fund of Jilin University (No. 101832018C070).

Cu(I)-catalyzed azide-alkyne specific reaction, popularly known as the "click chemistry reaction", is defined as an important molecular connection method, which can realize simple and efficient connection between specific small molecule groups at the molecular level. Because of its advantages such as high efficiency, high selectivity, mild conditions and few side reactions, click chemistry reaction has been widely used in proteomics analysis, including the identification of newly synthesized proteins and the identification of various post-translational modified proteins. Therefore, in-depth study of the reaction mechanism of click chemistry reaction in proteomics is very important for understanding the structure and function of proteins. The goal of this review is to highlight the progress of several important applications of click chemistry in proteomics analysis in recent years, and discuss the future trends of the click chemistry in proteomics.
- Click chemistry reaction,
- Proteomics,
- Review
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沈阳化工大学材料科学与工程学院沈阳 110142