Citation: AN Chun, DU Pei-Yao, ZHANG Zhen, LU Xiao-Quan. Rapid and Highly Selective Detection of Copper Ion with Glutathione-capped Gold Nanoclusters[J]. Chinese Journal of Analytical Chemistry, ;2020, 48(3): 355-362. doi: 10.19756/j.issn.0253-3820.191668 shu

Rapid and Highly Selective Detection of Copper Ion with Glutathione-capped Gold Nanoclusters

AN Chun ^1, ,
DU Pei-Yao ¹ ,
ZHANG Zhen ¹ ,
LU Xiao-Quan ^1,2

1.
Tianjin Key Laboratory of Molecular Optoelectronic Science, Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, China;
2.
Key Laboratory of Bioelectrochemistry&Environmental Analysis of Gansu Province, College of Chemistry&Chemical Engineering, Northwest Normal University, Lanzhou 730070, China

Received Date: 13 November 2019
Revised Date: 3 January 2020

Fund Project: This work was supported by the National Natural Science Foundation of China (Nos. 21575115, 21705117)

The gold nanoclusters (AuNCs) with red fluorescence were synthesized using glutathione (GSH) as protectants and reductants, which displayed high selectivity to Cu²⁺ in water and rat serum. Due to the coordination of Cu²⁺ with the capping ligand of AuNCs, ligand-metal charge transfer (LMCT) or ligand-metal-metal charge transfer (LMMCT) was blocked, and the fluorescence of the gold cluster was quenched, so Cu²⁺ could be selectively detected. Moreover, the gold cluster displayed ultrahigh selectivity and excellent sensitivity to Cu²⁺, which could shield 16 other interfering substances, with a detection limit of 23 nmol/L(S/N=3). In addition, the reliability of AuNCs was also verified by detection of Cu²⁺ in water samples and rat serum with satisfactory recoveries. This study provides a simple, fast and reliable method to detect Cu²⁺. The method is expected to be extended to the diagnosis of diseases, biological imaging, biomarker, water quality analysis, etc.
- Gold nanoclusters,
- Fluorescence,
- Copper ions,
- Detection
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