Citation: LU Chao-Fen, ZHANG Ju-Mei, QIN Yu, ZHENG Li-Yan, CAO Qiu-E, ZHOU Chuan-Hua. Construction and Application of Metal-Organic Polyhedra-based Colorimetric Assay[J]. Chinese Journal of Analytical Chemistry, ;2020, 48(8): 997-1003. doi: 10.19756/j.issn.0253-3820.191623 shu

Construction and Application of Metal-Organic Polyhedra-based Colorimetric Assay

School of Chemical Science and Technology, Experiment Centre of Chemistry and Chemical Engineering, Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, Yunnan University, Kunming 650091, China

Received Date: 23 October 2019
Revised Date: 28 May 2020

Fund Project: This work was supported by the National Natural Science Foundation of China (Nos. 21505119, 21465025).

A simple and highly sensitive colorimetric assay method for ascorbic acid (AA) detection was developed based on the high catalytic activity of metal-organic polyhedron (MOP) and the reducibility of ascorbic acid. Copper metal-organic polyhedra nanorods (Cu-MOP) exhibited high peroxidase-mimicking activity, which were capable of catalyzing the oxidation of the 3,3',5,5'-tetramethylbenzidine (TMB) in the presence of H₂O₂. The presence of AA in detection solution triggered the decomposition of Cu-MOP by reducing Cu²⁺, which weakened peroxidase-mimicking activity of Cu-MOP dramatically. As a result, the catalytic oxidation reaction of TMB by Cu-MOP in the presence of H₂O₂ was inhibited, and AA could be detected specifically by detecting the solution color and its absorbance. The calibration graph for the determination of AA was linear in the range of 1.0-30.0 μmol/L and 40.0-200 μmol/L, and the detection limit (S/N=3) was 0.68 μmol/L. The sensor showed many advantage such as simple, fast and without the need of complicated instruments, and could be applied to the determination of AA in drugs with satisfactory results.
- Copper metal-organic polyhedra nanorods,
- 3,3',5,5'-Tetramethylbenzidine,
- Ascorbic acid,
- Colorimetric assay
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