Citation:
HAO Yu-Jia, ZHU Guang-Ming. Advances in Fabrication of Polydiacetylene Vesicles and Their Applications in Medical Detection[J]. Chinese Journal of Analytical Chemistry,
;2020, 48(2): 164-173.
doi:
10.19756/j.issn.0253-3820.191562
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Polydiacetylenes (PDAs) have received increasing attention as smart materials owing to their unique optical and electronic properties. PDAs are the most commonly synthesized as self-assembled bilayer vesicles via 1,4 addition polymerization. Vesicles are often perceived as closely mimicking the cell membrane, thus functioning as convenient biomimetic platforms. PDAs undergo colorimetric and fluorescent transition in response to external stimuli. Therefore, PDA vesicles can be used for medical detection, such as bacteria, viruses, proteins, and enzymes, etc. In this review, the preparation of PDA vesicle sensing systems and the mechanism of solid phase polymerization are summarized. The relative applications of PDA vesicle sensing systems in medical detection are introduced. Besides, the shortcomings and issues to be solved, and future directions are also discussed and prospected.
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