Citation: HUANG Xi, LIU Hui-Hui, MAO Lan-Qun, XIONG Cai-Qiao, NIE Zong-Xiu. Progress of Mass Spectrometry Imaging in Neuroscience[J]. Chinese Journal of Analytical Chemistry, ;2019, 47(10): 1592-1600. doi: 10.19756/j.issn.0253-3820.191432 shu

Progress of Mass Spectrometry Imaging in Neuroscience

HUANG Xi ^1,2, ,
LIU Hui-Hui ^1,2 ,
MAO Lan-Qun ^1,2 ,
XIONG Cai-Qiao ^1,2 ,
NIE Zong-Xiu ^1,2

1.
Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China;
2.
University of Chinese Academy of Sciences, Beijing 100049, China

Received Date: 22 July 2019
Revised Date: 3 September 2019

Fund Project: This work was supported by the National Natural Science Foundation of China (Nos. 21790390, 21790392, 21625504).

Brain is the central organ of the human nervous system with complex functionality and complicated structure. The chemicals in brain play important roles in metabolism and signal transduction. It is a challenge for scientists to characterize and analyze these chemicals due to their diversity in chemical property and concentration. Mass spectrometry imaging as a new technique is able to screen the spatial distribution of various molecules simultaneously without labeling and has been broadly applied in the study of neurodegenerative disease, brain tumor and pharmacokinetic in brain. This review introduces the principle and new technique of mass spectrometry imaging, and focuses on its typical applications in neuroscience published in recent years.
- Mass spectrometry imaging,
- Neuroscience,
- Matrix-assisted laser desorption ionization,
- Desorption electrospray ionization,
- Review
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