Citation: CHEN Chao-Yu, MA Yan, FANG Qun. Advances in Microfluidic Organ-on-a-Chip Systems[J]. Chinese Journal of Analytical Chemistry, ;2019, 47(11): 1711-1720. doi: 10.19756/j.issn.0253-3820.191423 shu

Advances in Microfluidic Organ-on-a-Chip Systems

CHEN Chao-Yu ^1, ,
MA Yan ² ,
FANG Qun ¹

1.
Institute of Microanalytical Systems, Department of Chemistry, Zhejiang University, Hangzhou 310058, China;
2.
Institute of Cancer and Basic Medicine(ICBM), Chinese Academy of Sciences;Cancer Hospital of the University of Chinese Academy of Sciences;Zhejiang Cancer Hospital, Hangzhou 310022, China

Received Date: 19 July 2019
Revised Date: 9 September 2019

Fund Project: This work was supported by the National Natural Science Foundation of China (Nos. 21435004, 21827806).

Organ-on-a-chip systems aim to build integrated microsystems to simulate human tissue and organ functions by utilizing the control ability of microfluidic chips to microfluids, cells and their micro-environment, for providing low-cost screening and research models close to in-vivo physiological and pathological conditions for evaluation of effectiveness and biosafety of drugs and vaccines, as well as biomedical research. In this review, the progress of organ-on-a-chip systems based on channels, chambers and membranes are introduced according to their structures and cell culturing modes.
- Organ-on-a-chip,
- Dynamic culture,
- Microfluidics,
- Review
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