Citation: ZHANG Yang-Yang, HAN Chao, ZHAO Zhen-Wen. Research Progress of Matrix Assisted Laser Desorption Ionization Mass Spectrometry Imaging of Alzheimer's Disease Brain[J]. Chinese Journal of Analytical Chemistry, ;2019, 47(10): 1622-1628. doi: 10.19756/j.issn.0253-3820.191421 shu

Research Progress of Matrix Assisted Laser Desorption Ionization Mass Spectrometry Imaging of Alzheimer's Disease Brain

1.
Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China;
2.
University of Chinese Academy of Sciences, Beijing 100049, China

Received Date: 19 July 2019
Revised Date: 7 September 2019

Fund Project: This work was supported by the National Natural Science Foundation of China (Nos. 21874142, 21575146, 21635008, 21621062).

Alzheimer's disease (AD) is an age-related neurological disorder, affecting millions of people around the world, but the exact cause of the disease remains unclear. Matrix assisted laser desorption ionization mass spectrometry imaging (MALDI MSI) analysis technology not only enables material identification, but also spatially images the analytes. In recent years, MALDI MSI technique has been widely applied to the study of the distribution of β-amyloid (Aβ) and lipid in AD brain tissue. The principle, methodology of MALDI MSI and related research progress of the mechanism of AD treatment were reviewed in this paper, and the prospects for its development were also anticipated.
- Alzheimer's disease,
- Matrix assisted laser desorption ionization mass spectrometry imaging,
- Review
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沈阳化工大学材料科学与工程学院沈阳 110142