Citation: YU Zhong-Ning, ZHANG Zhuo-Min, LI Gong-Ke. Application of Microextraction in Neurotransmitter Analysis[J]. Chinese Journal of Analytical Chemistry, ;2019, 47(10): 1580-1591. doi: 10.19756/j.issn.0253-3820.191418 shu

Application of Microextraction in Neurotransmitter Analysis

School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China

Received Date: 19 July 2019
Revised Date: 27 August 2019

Fund Project: This work was supported by the National Natural Science Foundation of China (Nos. 21475154, 21675178, 21976213), and the Research and Development Plan for Key Areas of Food Safety in Guangdong Province of China (No. 2019B020211001).

Neurotransmitters play an important regulatory role in organisms as endogenous compounds. Accurate determination of neurotransmitters in biological samples is of great significance in early diagnosis of diseases, drug development, basic medical research and other fields. However, it is difficult to achieve accurate analysis because of their complex matrix composition and extremely low concentrations. Therefore, the key to improve the sensitivity and accuracy for the analysis of trace neurotransmitters in complex biological samples is to develop efficient sample pretreatment technology. Microextraction technology is a green extraction technology based on microscale enrichment media which is considered as an excellent pretreatment technology for the analysis of endogenous substances in biological samples due to its low cost, convenient use, adaptability to nondestructive analysis and environmental friendliness. In this paper, we systematically reviewed the application of solid-phase microextraction, micro-solid-phase extraction, and liquid phase microextraction technologies in the high-efficiency enrichment and analysis of trace neurotransmitters in biological samples.
- Microextraction technology,
- Neurotransmitters,
- Biological samples,
- Review
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