Citation: LIU Zhuo-Liang, TAO Cheng-An, WANG Jian-Fang. Progress on Applications of G-quadruplex in Biochemical Analysis[J]. Chinese Journal of Analytical Chemistry, ;2020, 48(2): 153-163. doi: 10.19756/j.issn.0253-3820.191399 shu

Progress on Applications of G-quadruplex in Biochemical Analysis

1.
Department of Biology and Chemistry, College of Liberal Arts and Sciences, National University of Defense Technology, Changsha 410073, China;
2.
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China

Received Date: 13 July 2019
Revised Date: 13 November 2019

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 21705163), the Natural Science Foundation of Hunan Province, China (No. 2019JJ50737), the Research Project of the National University of Defense Technology (No. ZK18-03-39) and the Open Subject of State Key Laboratory of Chemo/Biosensing and Chemometrics (No. 2017011).

G-quadruplex is a special secondary structure of nucleic acid. G-quadruplex can bind with hemin to form DNAzyme with peroxidase activity, and also it can enhance the fluorescence intensity of some dyes. As one of the functional nucleic acids, G-quadruplex is widely used in various biochemical analyses due to its high stability, specificity and flexibility. The application of G-quadruplex in biochemical analysis and its application prospects are briefly introduced.
- G-quadruplex,
- Functional nucleic acid,
- DNAzyme/RNAzyme,
- Biochemical analysis,
- Review
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沈阳化工大学材料科学与工程学院沈阳 110142