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Citation: LU Si-Min, YU Ru-Jia, LONG Yi-Tao. Real-Time Monitoring of Click Reaction Based on Confined Glass Nanopipette[J]. Chinese Journal of Analytical Chemistry, ;2019, 47(9): 1309-1313. doi: 10.19756/j.issn.0253-3820.191333 shu

Real-Time Monitoring of Click Reaction Based on Confined Glass Nanopipette

LU Si-Min ^1, ,
YU Ru-Jia ¹ ,
LONG Yi-Tao ^1,2

1.
School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China;
2.
The State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China

Received Date: 13 June 2019
Revised Date: 21 July 2019

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 21834001).

Click reaction is a reliable, powerful and selective method in material science, medical science and biochemistry. Monitoring of click reaction at single particle scale contributes to revealing anisotropy and mechanism of click reaction. In this study, electrochemically confined glass nanopipette was acted as a sensor to monitor the click reaction on a single gold nanoparticle (Au NP). Driven by electroosmotic flow, Au NPs modified with alkynyl moved towards the inner channel of glass nanopipette. When Cu⁺ was presented in the inner channel, alkynyl on the surface of Au NPs would react with azide on the gold layer. Click reaction resulted in the cross-linking between Au NPs and gold layer, which hindering the movement of Au NPs. Hence, Au NPs were transitorily resided near the orifice of glass nanopipette, which was responded to a higher frequency of ionic blockage and a longer blockage time. The method proposed here paved a way for real-time monitoring of chemical reaction.
- Click reaction,
- Confined glass nanopipette,
- Electrochemically confined effect,
- Volume exclusion effect,
- Ionic blockage
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