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Citation: WANG Chun, YUAN Wen-Feng, GU Chuan-Kun, WANG Chang-Hai, MA Qiang. Determination of 11 Kinds of Quinolones Residues in Blood by Ultra-Performance Liquid Chromatography-Hybrid Triple Quadrupole-Linear Ion Trap Mass Spectrometry[J]. Chinese Journal of Analytical Chemistry, ;2019, 47(11): 1832-1841. doi: 10.19756/j.issn.0253-3820.191279 shu

Determination of 11 Kinds of Quinolones Residues in Blood by Ultra-Performance Liquid Chromatography-Hybrid Triple Quadrupole-Linear Ion Trap Mass Spectrometry

1.
Chinese Academy of Inspection and Quarantine, Beijing 100176, China;
2.
College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, China

Received Date: 12 May 2019
Revised Date: 15 July 2019

Fund Project: This work was supported by the National Key R&D Program of China (No. 2016YFF0203701).

A method for determination of 11 kinds of quinolones residues in blood was developed using supramolecular solvent-based dispersive liquid-liquid microextraction followed by ultra-performance liquid chromatography-hybrid triple quadrupole-linear ion trap mass spectrometry. The supramolecular solvent was prepared with hexanol as extraction solvent and tetrahydrofuran as dispersing agent for dispersive liquid-liquid microextraction of blood samples. The main parameters such as the composition and amount of supramolecular solvent and vortex time were systemically investigated by both single factor and orthogonal experiments in combination with statistical analyses. Chromatographic separation was performed on a Waters ACQUITY UPLC BEH C₁₈ column (50 mm×2.1 mm, 1.7 μm) with mobile phases of acetonitrile and 0.15% aqueous formic acid solution. Data acquisition was carried out in multiple reaction monitoring-information dependent acquisition-enhanced product ion mode for qualitative and quantitative analyses. The 11 kinds of quinolones exhibited good linearity in their respective linear ranges, with correlation coefficients of better than 0.998. The limits of detection and quantitation were in the range of 0.1-0.8 μg/L and 0.4-2.0 μg/L, respectively. The average recoveries at low, medium, and high spiked levels ranged from 70.8% to 115.2% with relative standard deviations of 3.0%-11.5% (n=6).
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