Citation: WANG Ting-Ting, ZHANG Jie, WANG Shen-Shuai, WANG Xiu-Yun. Rational Design of Metal Organic Framework Nanocomposite-based Functionalized Interface for Simultaneous Electrochemical Determination of Purine Metabolites[J]. Chinese Journal of Analytical Chemistry, ;2019, 47(7): 1021-1028. doi: 10.19756/j.issn.0253-3820.191153 shu

Rational Design of Metal Organic Framework Nanocomposite-based Functionalized Interface for Simultaneous Electrochemical Determination of Purine Metabolites

School of Chemistry, Dalian University of Technology, Dalian 116024, China

Received Date: 21 March 2019
Revised Date: 29 April 2019

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 21205008) and the Fundamental Research Funds for the Central Universities (No. DUT16LK25).

The simultaneous and sensitive detection of metabolites of DNA (uric acid (UA), xanthine (XA) and hypoxanthine (HX)) is of great significance for the early diagnosis and prevention of related diseases caused by abnormal metabolism. In this study, hydroxyl functionalized metal-organic framework (OH-MOFs) and electrochemically reduced graphene oxide (ERGO) nano-functional interface was designed and constructed based on the synergic effect of Fe terephthalate OH-MOFs (OH-MIL-101(Fe) and ERGO for simultaneous detection of UA, XA and HX in blood. Nano-composites were prepared by ultrasonic mixing method, and were characterized by X-ray diffraction (XRD), Fourier transform infrared (FT-IR) and UV-Vis spectroscopic methods. By casting the surface of glassy carbon electrode (GCE) with the composite and electrochemical reduction of the modified electrode, OH-MOFs-ERGO/GCE was obtained. Under the optimum conditions, the oxidation peak currents of UA, XA and HX were linearly correlated to their concentrations in the ranges of 0.20-1150 μmol/L, 0.15-800 μmol/L, and 0.40-600 μmol/L, respectively. The detection limits for UA, XA and HX were 0.12, 0.10 and 0.20 μmol/L (S/N=3), respectively. The recoveries of UA, XA and HX in real serum samples were between 99.5% and 105.8%. The proposed electrode was expected to provide a simple and easy detection method for the physiological and pathological study of purine metabolism.
- Iron-based terephthalate metal-organic framework,
- Electrochemicaaly reduced graphene,
- Simultaneous detection,
- Purine metabolites
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