Citation: LIAN Xian-Hui, WANG Chun, MENG Xian-Shuang, BAI Hua, SUN Xiao-Jie, XUE Hong-Yu, MA Qiang. Determination of 10 Kinds of Caine-Type Prohibited Ingredients in Cosmetics by Ultra-Performance Liquid Chromatography-Differential Mobility Spectrometry-Mass Spectrometry[J]. Chinese Journal of Analytical Chemistry, ;2019, 47(5): 756-764. doi: 10.19756/j.issn.0253-3820.191040 shu

Determination of 10 Kinds of Caine-Type Prohibited Ingredients in Cosmetics by Ultra-Performance Liquid Chromatography-Differential Mobility Spectrometry-Mass Spectrometry

LIAN Xian-Hui ^1,2, ,
WANG Chun ^1,3 ,
MENG Xian-Shuang ¹ ,
BAI Hua ¹ ,
SUN Xiao-Jie ⁴ ,
XUE Hong-Yu ² ,
MA Qiang ¹

1.
Chinese Academy of Inspection and Quarantine, Beijing 100176, China;
2.
School of Life Science and Medicine, Dalian University of Technology, Panjin 124221, China;
3.
College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, China;
4.
SCIEX Asia Pacific Application Support Center, Beijing 100015, China

Received Date: 19 January 2019
Revised Date: 24 February 2019

Fund Project: This work was supported by the National Key R&D Program of China (No. 2016YFF0203701) and the Program of Standardization Administration of China (No. 20173894-T-607).

An analytical method for determination of 10 kinds of caine-type prohibited ingredients in cosmetics was developed using supramolecular solvent-based dispersive liquid-liquid microextraction followed by ultra-performance liquid chromatography coupled with differential mobility spectrometry-mass spectrometry. The supramolecular solvent was prepared with dodecanol as extraction solvent and tetrahydrofuran as dispersing agent for dispersive liquid-liquid microextraction of cosmetic samples under vortexing. The effects of the composition and amount of supramolecular solvent and vortex time on the extraction efficiency and the separation of isomers by differential mobility spectrometry were systemitically investigated. Results showed that the sample could be effectively extracted by 4 mL of supramolecular solvent consisting of dodecanol and tetrahydrofuran after vortexing for 3 min. Under the optimized conditions including carrier gas, separation voltage and compensation voltage, the isomers of benzocaine and tricaine could be well separated by differential mobility spectrometry for qualitative confirmation and quantitative determination, which could hardly be chromatographically separated. The 10 kinds of caine-type compounds exhibited good linearity in their respective concentration ranges, with correlation coefficients of better than 0.99. The limits of detection and quantitation were 0.2-8.0 μg/kg and 0.4-20.0 μg/kg, respectively. The average recoveries at low, medium and high spiked levels ranged from 70.7% to 94.7% with relative standard deviations of 1.2% to 12.7% (n=6). The method is simple, rapid, efficient, and is suitable for the simultaneous determination of the 10 kinds of caine-type prohibited ingredients in cosmetics.
- Supramolecular solvent,
- Dispersive liquid-liquid microextraction,
- Cosmetics,
- Differential mobility spectrometry-mass spectrometry
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