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Citation: CHEN Kai, ZHANG Ying-Chun, ZHAO Guan-Fang. Expansion Microscopy Imaging Technique and Its Application[J]. Chinese Journal of Analytical Chemistry, ;2019, 47(5): 643-651. doi: 10.19756/j.issn.0253-3820.181464 shu

Expansion Microscopy Imaging Technique and Its Application

1.
School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150090, China;
2.
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China

Received Date: 16 July 2018
Revised Date: 17 March 2019

Fund Project: This work was supported by the Postdoctoral Scientific Research Developmental Fund of Heilongjiang Province, China (No. LBH-Q17076), the Foundation of Science and Technology Department of Jilin Province (No. 20170623027TC) and the National Key R & D Program of China (No. 2017YFC1601905).

Due to the limitation of optical diffraction, traditional optical microscopes have insufficient resolution to observe subcellular microstructures. Super-resolution microscopy, awarded the Nobel Prize in Chemistry in 2014, has been extensively used in single-molecule imaging of microstructures. As a new super-resolution microscope, expansion microscope has the advantages of short imaging time and can mark dense biological macromolecules. This review describes the imaging principles and characteristics of expansion microscope, and reviews its applications in subcellular structures, neurobiology and other fields.
- Expansion microscopy,
- Super-resolution imaging,
- Gel,
- Review
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