Citation: Ya-Wen REN, Hang-Na HU, Jun ZHANG, Xin-Jing ZHUANG, Dong-Ping LI, Yong-Xiu LI. Characterization and DNA Interaction of Lanthanide Complexes Based on Thiourea Ligand[J]. Chinese Journal of Structural Chemistry, ;2021, 40(1): 47-54. doi: 10.14102/j.cnki.0254–5861.2011–2760 shu

Characterization and DNA Interaction of Lanthanide Complexes Based on Thiourea Ligand

a.
Department of Chemistry, Nanchang University, Nanchang 330031, China
b.
Key Laboratory of Functional Molecule Design and Interface Process, Anhui Jianzhu University, Hefei 230022, China

Corresponding author: Dong-Ping LI, nculdp@126.com
Received Date: 8 February 2020
Accepted Date: 1 April 2020

Fund Project: the National Natural Science Foundation of China 21101090the National Natural Science Foundation of China 21561021

Figures(3)

Three isostructural lanthanide complexes, namely [Ln(L)₃·CH₃OH] (Ln = Tb(1), Dy(2), Ho(3), HL = N-(pyridin-2-ylcarbamothioyl)benzamide), were successfully synthesized and characterized by IR, UV, elemental analysis, single-crystal X-ray diffraction and DNA-biding analysis. X-ray single-crystal diffractions show that the family of lanthanide complexes crystallizes in monoclinic C2/c space group. Each lanthanide atom is coordinated with three carbonyl-O atoms, three pyridyl-N atoms and three imine-N atoms from three distinct L^–1 ligands, forming a distorted tricapped trigonal prism. The binding properties of complexes with ct-DNA were studied by simulating the physiological environment of human body. The results suggest that compounds could bind with ct-DNA through interaction under a spontaneous process.
- lanthanide complex,
- crystal structure,
- DNA-binding activity
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