Citation: Su-Su SUN, Qing LI, Wei GAO, Xiao-Tian LI, Lai CHEN, Jin-Lin ZHANG. Synthesis, Crystal Structure and Anti-TMV Activity of (Z)-4-[3-(4-Methyl-1,2,3-thiadiazol-5-yl)-3-(4-trifluoromethylphenyl)acryloyl]morpholine[J]. Chinese Journal of Structural Chemistry, ;2021, 40(1): 109-113. doi: 10.14102/j.cnki.0254–5861.2011–2753 shu

Synthesis, Crystal Structure and Anti-TMV Activity of (Z)-4-[3-(4-Methyl-1,2,3-thiadiazol-5-yl)-3-(4-trifluoromethylphenyl)acryloyl]morpholine

College of Plant Protection, Hebei Agricultural University, Baoding 071001, China

Corresponding author: Lai CHEN, chenlai@hebau.edu.cn Jin-Lin ZHANG, zhangjinlin@hebau.edu.cn
Received Date: 3 February 2020
Accepted Date: 10 April 2020

Fund Project: Youth Natural Science Foundation of Hebei Province B2019204030the starting Scientific Research Foundation for the introduced talents of Hebei Agricultural University 201842the National Natural Science Foundation of China 31871981Modern Agriculture Industry Technology System Innovation Team of Phase II of Hebei Province HB2018020205

Figures(3)

The target compound (Z)-4-[3-(4-methyl-1,2,3-thiadiazol-5-yl)-3-(4-trifluoromethylphenyl)acryloyl]morpholine was synthesized by the nucleophilic substitution, Horner-Emmons reaction, ester hydrolysis, and condensation. Its structure was characterized by NMR, H RMS and single-crystal X-ray diffraction. The crystal of the target compound belongs to monoclinic system, space group P2₁ with a = 11.5058(15), b = 6.6626(10), c = 23.184(3) Å, V = 1777.3(4) Å³, Z = 8, D_c = 1.496 Mg/m³, F(000) = 792 and μ = 0.229 mm^–1. X-ray analysis indicated C–H⋯O intermolecular H-bonds in this crystal structure. The target compound exhibited 53% curative activity against TMV.
- 1,2,3-thiadiazole,
- cinnamic amide,
- synthesis,
- crystal structure,
- anti-TMV activity
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