Citation: Jing LI, Jiang-Tao LI. Two Cu(II) and Co(II)-based Coordination Polymers Based on the N, S-donor Ligand: Crystal Structures and Anticancer Activity Evaluation[J]. Chinese Journal of Structural Chemistry, ;2020, 39(10): 1849-1854. doi: 10.14102/j.cnki.0254–5861.2011–2411 shu

Two Cu(II) and Co(II)-based Coordination Polymers Based on the N, S-donor Ligand: Crystal Structures and Anticancer Activity Evaluation

Jing LI ,
Jiang-Tao LI ^,

Key Laboratory for Surface Engineering and Remanufacturing in Shaanxi Province, School of Chemical Engineering, Xi'an University, Xi'an 710065, China

Corresponding author: Jiang-Tao LI, lijiangtao-968@xawl.edu.cn
Received Date: 18 April 2019
Accepted Date: 3 September 2019

Fund Project: the Industrial Research Project of Science and Technology, Department of Shaanxi Province 2017GY-126

Figures(5)

Two new Cu(II) and Co(II)-based coordination polymers with the chemical formulae of {Cu(L)₂]·DMF}_n (1) and {[Co(L)₂]·2DMF}_n (2) have been successfully constructed from a pyridine-substituted N-heterocyclic thioamide ligand, namely [3, 4΄-bipyridine]-2΄-thiol (HL). Complex 1 is composed of two identical coordination networks with dia topology interpenetrating into each other, and shows 1-D microporous channels along the a axis. Complex 2 is assembled by 2-D square-grid layers stacked in an eclipsed fashion to give 1-D large square channels along the b axis. CCK-8 was used for the detection of cancer cells. Results indicated that compound 1 exhibited stronger anti-cancer activity than compound 2 on the H1650 cancer cells. The Annexin V-FITC/PI was recommended for cancer cell apoptosis, and the western blot was applied for the detection of PI3K/AKT pathway activation.
- coordination polymer,
- N, S-donor ligand,
- CCK-8 assay,
- anticancer activity
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沈阳化工大学材料科学与工程学院沈阳 110142