Citation: ZHAO Ling-Ling, ZHAI Fu-Min, XIE Ming-Chao, QI Gang. Study on the Synthesis and Antitumor Activity of New Indolocarbazole Compounds[J]. Chinese Journal of Structural Chemistry, ;2016, 35(2): 205-211. doi: 10.14102/j.cnki.0254-5861.2011-0967 shu

Study on the Synthesis and Antitumor Activity of New Indolocarbazole Compounds

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a Department of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng 224051, China;
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b Jiangsu Wanquan Pharmaceutical Biotechnology Company, Taizhou 225300, China;
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c Binhai County Safety Supervision Bureau, Yancheng 224500, China

Received Date: 2 September 2015
Available Online: 1 December 2015
Fund Project:

A series of new antitumor compounds having indolecarbazole structures were designed and synthesized. The methoxy substituted indolecarbazole parent nucleus, which was firstly synthesized, is condensed with bromine substituted amino acid methyl ester to produce the target compounds. The target compounds were performed with methylthiazolyldiphenyl-tetrazolium bromide (MTT) in vitro cytotoxin activity test and the results showed that compounds CZ-1, CZ-3 and CZ-6 have higher activity against human colon cancer (HT-29) and (HCT-8), hepatocellular carcinoma (Bel-7402), NSCLC (A549) and breast cancer (MCF-7) cells as compared to the positive control JDC-108.
- indolecarbazole,
- antitumor activity,
- cytotoxin activity
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沈阳化工大学材料科学与工程学院沈阳 110142