Citation: TAI Xi-Shi, WANG Xin, YOU Hai-Ying. Synthesis, Crystal Structure and Antitumor Activity of a New Zn(II) Complex Based on N-Acetyl-L-phenylalanine and 1,10-Phenanthroline[J]. Chinese Journal of Structural Chemistry, ;2016, 35(4): 586-590. doi: 10.14102/j.cnki.0254-5861.2011-0910 shu

Synthesis, Crystal Structure and Antitumor Activity of a New Zn(II) Complex Based on N-Acetyl-L-phenylalanine and 1,10-Phenanthroline

1.
a College of Chemistry and Chemical Engineering, Weifang University, Weifang 261061, China;
2.
b Department of Chemistry, Qinghai Normal University, Xining 810008, China;
3.
c Weifang University of Science and Technology, Shouguang 262700, China

Received Date: 23 July 2015
Available Online: 22 October 2015
Fund Project: This work was supported by the National Natural Science Foundation of China (No. 21171132) (No. 21171132)

A new Zn(Ⅱ) complex,[Zn(L)₂(phen)(H₂O)] (1, HL=N-acetyl-L-phenylalanine, phen=1,10-phenanthroline) has been synthesized and characterized by elemental analysis, IR and X-ray single-crystal diffraction analysis. The Zn(Ⅱ) complex belongs to monoclinic, space group P2₁ with a=12.6749(13), b=5.5965(6), c=22.985(2) Å, β=104.296(2)°, V=1580.0(3) Å³, Z=2, M_r=676.02, Dc=1.421 μg·m^-3, μ=0.833 mm^-1, F(000)=704, and the final R=0.0460, wR=0.0899 for 4422 observed reflections with I > 2σ(I). The molecules form a 1D chained structure by hydrogen bonds. The antitumor activities of Zn(Ⅱ) complex against human hepatoma SMMC-7721 cells, human lung adenocarcinoma A549 cells and human colon carcinoma WiDr cells have also been investigated.
- N-acetyl-L-phenylalanine,
- Zn(II) complex,
- synthesis,
- crystal structure,
- antitumor activity
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沈阳化工大学材料科学与工程学院沈阳 110142