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Citation: Zimo Shen, Tongwei Zhang, Zhiyi Zhu, Zonghao Gong, Qing Feng, Jinyi Yang, Zhen Li, Min Liu, Wei Qi. From Alkaloid to Anticancer Agent: The Transformative Journey of Camptothecin[J]. University Chemistry, ;2025, 40(10): 161-165. doi: 10.12461/PKU.DXHX202411027 shu

From Alkaloid to Anticancer Agent: The Transformative Journey of Camptothecin

Zimo Shen ¹ ,
Tongwei Zhang ¹ ,
Zhiyi Zhu ¹ ,
Zonghao Gong ¹ ,
Qing Feng ² ,
Jinyi Yang ³ ,
Zhen Li ³ ,
Min Liu ² ,
Wei Qi ²

1.
School of Nursing, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;
2.
School of Chemical Engineering and Chemistry, Huazhong University of Science and Technology, Wuhan 430074, China;
3.
Henan Jinshu Network Technology Co., Ltd., Zhengzhou 410100, China

Received Date: 6 November 2024
Revised Date: 24 February 2025

Camptothecin, a potent anticancer agent derived from traditional Chinese medicine, serves as the focal point of this article. Through the imaginative lens of a science fiction narrative, the article depicts camptothecin’s battle against tumor cells. Employing a combination of scientific rigor and engaging language, it elucidates the compound’s properties, mechanisms of action, and recent research progress in structural modifications, functional enhancements, and clinical applications.
- Camptothecin,
- Antitumor,
- Structural modification,
- Drug delivery system
1. [1]
2. [2]
3. [3]
4. [4]
5. [5]
6. [6]
7. [7]
8. [8]
9. [9]
1. [1]
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2. [2]
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3. [3]
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4. [4]
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5. [5]
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6. [6]
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7. [7]
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8. [8]
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9. [9]
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10. [10]
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11. [11]
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12. [12]
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13. [13]
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14. [14]
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15. [15]
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16. [16]
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17. [17]
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18. [18]
  Aiai WANG , Lu ZHAO , Yunfeng BAI , Feng FENG . Research progress of bimetallic organic framework in tumor diagnosis and treatment. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1825-1839. doi: 10.11862/CJIC.20240225
19. [19]
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20. [20]
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