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Citation: Huijuan Liao, Yulin Xiao, Dong Xue, Mingyu Yang, Jianyang Dong. Synthesis of 1-Benzyl Isoquinoline via the Minisci Reaction[J]. University Chemistry, ;2025, 40(7): 294-299. doi: 10.12461/PKU.DXHX202409092 shu

Synthesis of 1-Benzyl Isoquinoline via the Minisci Reaction

School of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi'an 710119, China

Corresponding author: Jianyang Dong, jydong@snnu.edu.cn
Received Date: 23 September 2024
Revised Date: 23 December 2024

The Minisci reaction is an efficient method for synthesizing alkyl-substituted N-heteroarenes, involving the addition of alkyl radicals to N-heteroarenes under acidic and oxidative conditions. In this study, 1-benzyl isoquinoline was synthesized through the Minisci reaction using benzyl trimethylsilane as the alkyl radical precursor, ammonium persulfate ((NH₄)₂S₂O₈) as the oxidant, and dimethyl sulfoxide (DMSO) as the solvent. This experiment serves as a research-based laboratory exercise for junior undergraduates at our university, aiming to enhance students' scientific research and experimental operation skills, and stimulate innovative thinking.
- Benzyl trimethylsilane,
- Isoquinoline,
- Minisci reaction,
- Teaching experiment
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