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Citation: Benhua Wang, Chaoyi Yao, Yiming Li, Qing Liu, Minhuan Lan, Guipeng Yu, Yiming Luo, Xiangzhi Song. 一种基于香豆素氟离子荧光探针的合成、表征及性能测试——“科研反哺教学”在有机化学综合实验教学中的探索与实践[J]. University Chemistry, ;2025, 40(6): 201-209. doi: 10.12461/PKU.DXHX202408070 shu

一种基于香豆素氟离子荧光探针的合成、表征及性能测试——“科研反哺教学”在有机化学综合实验教学中的探索与实践

College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China

Received Date: 15 August 2024
Revised Date: 25 September 2024

基于科研实验，深入融合有机化学基本理论和实验技术，开发了一项研究型有机化学综合实验。该实验以4-(二乙氨基)水杨醛为原料，通过亲核取代和Knoevenagel缩合反应，合成了一种基于香豆素荧光团的氟离子荧光探针。利用柱层析纯化产物，采用核磁共振技术对产物进行结构表征，最终使用紫外-可见光谱和荧光光谱分析了该探针对氟离子的检测性能。通过本实验，学生不仅加深了对有机化学反应基本原理的学习、牢固掌握了有机化学基本实验操作，而且深入了解有机荧光染料在分子检测和识别中的应用，实现了理论知识与实际应用的有机融合。本实验的“科研反哺教学”模式，有效地将科研创新与教学实践相融合，极大激发了学生学习理论知识的积极性和参与科研实践的热情，培养了学生们的科研素养和创新能力，实验教学效果显著。
- Research feedback teaching,
- Coumarin-based fluorescent probe,
- Fluoride ion,
- Organic chemistry
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