Citation: Shiyan Cheng, Yonghong Ruan, Lei Gong, Yumei Lin. Research Advances in Friedel-Crafts Alkylation Reaction[J]. University Chemistry, ;2024, 39(10): 408-415. doi: 10.12461/PKU.DXHX202403024 shu

Research Advances in Friedel-Crafts Alkylation Reaction

College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian Province, China

Received Date: 5 March 2024
Revised Date: 20 May 2024

The Friedel-Crafts alkylation reaction represents a pivotal organic transformation for the formation of carbon-carbon bonds, holding extensive applications within the realms of both organic synthesis and pharmaceutical chemistry. This article presents a comprehensive review of the mechanism underlying the Friedel-Crafts alkylation reaction, alongside recent advancements in various catalytic approaches, such as metal catalysis, organocatalysis, visible light photocatalysis, enzymatic and electrochemical catalysis. By merging cutting-edge scientific developments with undergraduate teaching content, this review endeavors to inspire students’ learning interests while fostering their capacity for innovative thinking.
- Friedel-Crafts alkylation,
- Organic synthesis,
- Catalysis
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