Citation: SUN Bin, LÜ Jianhua, JIN Jing, ZHAO Guiyan. Application of Quartz Crystal Microbalance with Dissipation in Biomedical Polymer Materials[J]. Chinese Journal of Applied Chemistry, ;2020, 37(10): 1127-1136. doi: 10.11944/j.issn.1000-0518.2020.10.200078 shu

Application of Quartz Crystal Microbalance with Dissipation in Biomedical Polymer Materials

SUN Bin ^a,b ,
LÜ Jianhua ^b ,
JIN Jing ^b,, ,
ZHAO Guiyan ^a,,

a.
College of Chemistry Chemical Engineering, and Environmental Engineering, Liaoning Shihua University, Fushun, Liaoning 113001, China
b.
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China

Corresponding author: JIN Jing, ZHAO Guiyan, gyzhao@lnpu.edu.cn; jjin@ciac.ac.cn
Received Date: 19 March 2020
Revised Date: 26 April 2020
Accepted Date: 22 May 2020

Fund Project: the Scientific Research Cultivation Fund of LSHU 2016PY-014the Talent Scientific Research Fund of LSHU 2016XJJ-001Supported by the National Science Foundation of China for General Program(No.51673196, No.21674115), the Scientific Research Cultivation Fund of LSHU(No.2016PY-014), the Talent Scientific Research Fund of LSHU(No.2016XJJ-001) and the Scientific Research Fund of Liaoning Provincial Education Department(No.L2019013)the National Science Foundation of China for General Program 21674115the National Science Foundation of China for General Program 51673196the Scientific Research Fund of Liaoning Provincial Education Department L2019013

Figures(6)

Quartz crystal microbalance (QCM) is an analytical technique based on the piezoelectric effect of quartz crystal, which can provide the information on the mass, thickness and viscoelasticity of the adsorbed layer on the surface of quartz crystal in real time, and thus obtain the surface molecular interaction relationship. Because of the unique viscoelastic analysis, QCM with dissipation (QCM-D) has been rapidly applied in the field of polymer material, especially for biomedical polymer materials. It has been used to evaluate the surface and interface interaction, mechanical property, and biocompatibility of biomedical biomaterials. In this review, the basic principle and theoretical model of QCM-D are briefly introduced. The application of QCM-D in the conformation of polymer chain, protein adsorption, biomolecular interactions, drug release and hydrogels in recent years are emphatically reviewed, and finally the future development trends of QCM-D is forecasted.
- quartz crystal microbalance with dissipation,
- biomedical polymer materials,
- viscoelasticity
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