Citation: ZHANG Sijia, XU Caina, CHEN Jie, TIAN Huayu, CHEN Xuesi. Enhancing T Cell Antitumor Activity by Regulating Tumor Metabolism[J]. Chinese Journal of Applied Chemistry, ;2020, 37(9): 977-984. doi: 10.11944/j.issn.1000-0518.2020.09.200164 shu

Enhancing T Cell Antitumor Activity by Regulating Tumor Metabolism

ZHANG Sijia ^a,b ,
XU Caina ^a ,
CHEN Jie ^a,b ,
TIAN Huayu ^a,b,, ,
CHEN Xuesi ^a,b

a.
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
b.
University of Science and Technology of China, Hefei 230026, China

Corresponding author: TIAN Huayu, thy@ciac.ac.cn
Received Date: 1 June 2020
Revised Date: 24 June 2020
Accepted Date: 17 July 2020

Fund Project: Supported by the National Natural Science Foundation of China(No.51925305, No.51873208, No.51520105004, No.51833010) and the Jilin Province Science and Technology Development Program(No.20180414027GH)National Natural Science Foundation of China No.51520105004National Natural Science Foundation of China No.51833010National Natural Science Foundation of China No.51925305National Natural Science Foundation of China No.51873208Jilin Province Science and Technology Development Program No.20180414027GH

Figures(4)

Tumor immunotherapy is a new technique for cancer treatment. However, the low clinical response rate of tumor immunotherapy at this stage seriously restricts its further application. The fundamental reason is that the immunosuppressive microenvironment of tumor tissue limits the antitumor activity of T cells, and the metabolic changes of tumor tissue play a key role in the formation of tumor immunosuppressive microenvironment. In this paper, we focus on enhancing the antitumor activity of T cells by regulating the aerobic glycolysis, amino acid metabolism and fatty acid metabolism of tumors. Finally, the current problems in the research of tumor metabolism regulation are proposed, and the development prospects of nanocarriers in the field of tumor metabolism are prospected.
- tumor metabolism,
- T cell antitumor activity,
- aerobic glycolysis,
- amino acid metabolism,
- fatty acid metabolism
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