Citation: HU Guowen, QIAO Yuling. Folic Acid-Carbon Dot Conjugates for Cancer Cell Targeting[J]. Chinese Journal of Applied Chemistry, ;2020, 37(9): 1003-1009. doi: 10.11944/j.issn.1000-0518.2020.09.200100 shu

Folic Acid-Carbon Dot Conjugates for Cancer Cell Targeting

HU Guowen ^a,, ,
QIAO Yuling ^b

a.
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China
b.
Beijing Institute of Biological Products Co. LTD, Beijing 100024, China

Corresponding author: HU Guowen, hugw@lzu.edu.cn
Received Date: 8 April 2020
Revised Date: 9 June 2020
Accepted Date: 1 July 2020

Figures(8)

Fluorescent nanobioprobes with cell-targeting specificity are promising to find important applications in bioanalysis, biomedicine, and clinical diagnosis. In this work, folic acid-carbon dot conjugates (FA-CDs) were prepared via hydrothermal method and 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride (EDC) chemistry. The as-prepared FA-CDs with low toxicity and high luminescence can specifically target cancer cells. The specificity of this receptor-mediated internalization was confirmed by comparing the uptake by Hela and NIH-3T3 cells. This work is of great significance for the early diagnosis of cancer cells.
- carbon dots,
- folic acid,
- nanobioprobe,
- targeting,
- cancer cell
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