Citation: ZHAO Kaichao, ZHAO Xu, YAN Xiuping. pH Reversibly Activated Asymmetric Cyanine Photosensitizer for Photodynamic Antibacterial[J]. Chinese Journal of Applied Chemistry, ;2020, 37(6): 620-626. doi: 10.11944/j.issn.1000-0518.2020.06.200092 shu

pH Reversibly Activated Asymmetric Cyanine Photosensitizer for Photodynamic Antibacterial

ZHAO Kaichao ¹ ,
ZHAO Xu ^2,3,4,, ,
YAN Xiuping ^2,3,4,,

a.
School of Chemical and Material Engineering, Jiangnan University, Wuxi, Jiangsu 214122, China
b.
Institute of Analytical Food Safety, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
c.
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
d.
International Joint Laboratory on Food Safety, Jiangnan University, Wuxi, Jiangsu 214122, China

Corresponding author: ZHAO Xu, zhaoxu2017@jiangnan.edu.cn YAN Xiuping, xpyan@jiangnan.edu.cn
Received Date: 27 March 2020
Revised Date: 19 April 2020
Accepted Date: 23 April 2020

Fund Project: Supported by the National Natural Science Foundation of China(No.21804056), the Natural Science Foundation of Jiangsu Province, China(No.BK20180581), China Postdoctoral Science Foundation(No.2018M630511), and the Fundamental Research Funds for the Central Universities(No.JUSRP11846, No.JUSRP51714B)the Fundamental Research Funds for the Central Universities JUSRP51714Bthe Natural Science Foundation of Jiangsu Province, China BK20180581the National Natural Science Foundation of China 21804056China Postdoctoral Science Foundation 2018M630511the Fundamental Research Funds for the Central Universities JUSRP11846

Figures(5)

The photodynamic bactericidal performance of a reversibly activated asymmetric cyanine (Acy) was studied. The results show that Acy can be specifically activated to produce singlet oxygen in the weakly acidic microenvironment of bacteria under the irradiation of 808 nm laser, and shows excellent photodynamic bactericidal effect on both E.coli and S.aureus, but has no photodynamic antibacterial effect under normal physiological condition. The specifically activated photodynamic feature of Acy effectively overcomes the shortcoming of non-specific damage to normal tissues in previous "always on" photosensitizers, making Acy promising for specific antibacteria.
- pH reversible activation,
- photodynamic antibacteria,
- near infrared,
- asymmetric cyanine
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