Citation: CHEN Hang, LIU Chundong, WANG Jianhua. Research Progress on Modification and Effects of Halogen on Nucleic Acid Drugs[J]. Chinese Journal of Applied Chemistry, ;2018, 35(5): 491-499. doi: 10.11944/j.issn.1000-0518.2018.05.170280 shu

Research Progress on Modification and Effects of Halogen on Nucleic Acid Drugs

Bioengineering College of Chongqing University, Chongqing 400044, China

Corresponding author: WANG Jianhua, wjh@cqu.edu.cn
Received Date: 10 August 2017
Revised Date: 10 October 2017
Accepted Date: 23 October 2017

Fund Project: the Natural Science Foundation of Chongqing, China Cstc2013jjB0011the Social Programs and Human Security in Chongqing Science Cstc2017shms-xdny0033the Technology Innovation Projects Cstc2017shms-xdny80006Supported by the Natural Science Foundation of Chongqing, China(No.Cstc2013jjB0011), the Social Programs and Human Security in Chongqing Science(No.Cstc2017shms-xdny0033), the Technology Innovation Projects(No.Cstc2017shms-xdny80006)

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The halogenation is an invaluable approach for structural modification of drugs in medicine chemistry development. It increases the lipo-solubility, influences on the space charge distribution and improves their drug metabolic activity. Nucleic acid, as antiviral agent, antitumor agent, interferon inducer and immunopotentiator, can also be modified by halogenation. In this review we will discuss the effect on the bioactivity of modified nucleic acids on pyrimidines, purines and ribose by halogenation, and summarize the latest developments in drug research and development of modified nucleic acid.
- halogenation,
- pyrimidine,
- purine,
- ribose,
- modification,
- effects
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