Citation: FENG Cui, MIN Man, XIE Rongrong, REN Jianhui, CHEN Lin. Synthesis and Antioxidant Activity of Coumarin Schiff Base Derivatives[J]. Chinese Journal of Applied Chemistry, ;2018, 35(5): 538-543. doi: 10.11944/j.issn.1000-0518.2018.05.170279 shu

Synthesis and Antioxidant Activity of Coumarin Schiff Base Derivatives

FENG Cui ^a ,
MIN Man ^b ,
XIE Rongrong ^a ,
REN Jianhui ^a ,
CHEN Lin ^a,,

a.
School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China
b.
College of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China

Corresponding author: CHEN Lin, chenlin128@126.com
Received Date: 10 August 2017
Revised Date: 6 December 2017
Accepted Date: 24 January 2018

Fund Project: Supported by the Science and Technology Planning Project of Guangdong Province, China(No.2012B061700040); the Medical Science and Technology Research Fund Project of Guangdong Province, China(No.201618171249486)the Medical Science and Technology Research Fund Project of Guangdong Province, China 201618171249486the Science and Technology Planning Project of Guangdong Province, China 2012B061700040

Figures(4)

Two Coumarin Schiff base derivatives were synthesized from 2, 3, 4-trimethoxybenzaldehyde by demethylation, Knoevenagel and nucleophilic addition reaction. Structures of the corresponding products were elucidated through the analysis of ¹H NMR and MS spectra. The antioxidant activities of two derivatives were evaluated by quenching 2, 2'-diphenyl-1-picrylhydrazyl radical(DPPH), 2, 2'-azinobis(3-ethylbenzothiazoline-6-sulphonate) ammonium salt cationic radical(ABTS), and hydroxyl free radical. The result shows that the target compounds can quench the three types of free radicals. Compared to 7, 8-dimethoxy-3-aminocoumarin, two coumarin Schiff base derivatives have higher quenching activity for DPPH and hydroxyl free radical and have higher antioxidant activity.
- coumarin Schiff base,
- antioxidant
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