Citation: HE Daqing, JIANG Shangfei, CHEN Yu, WEN Lijun, TANG Yidi, LI Xinyu. Synthesis and DNA Cleavage Activity of Pyrazinedimethylformamide Bridged Apigenin Copper(Ⅱ) Complex[J]. Chinese Journal of Applied Chemistry, ;2017, 34(10): 1172-1176. doi: 10.11944/j.issn.1000-0518.2017.10.170124 shu

Synthesis and DNA Cleavage Activity of Pyrazinedimethylformamide Bridged Apigenin Copper(Ⅱ) Complex

HE Daqing ^a ,
JIANG Shangfei ^b ,
CHEN Yu ^a ,
WEN Lijun ^a,, ,
TANG Yidi ^a ,
LI Xinyu ^a

a.
College of Pharmacy, Hainan Medical College, Haikou 571199, China
b.
Institute of Basic Medicine and Life Science, Hainan Medical College, Haikou 571199, China

Corresponding author: WEN Lijun, wenlijun3467@163.com
Received Date: 21 April 2017
Revised Date: 5 June 2017
Accepted Date: 3 July 2017

Fund Project: the National Training Project of Innovation and Entrepreneurship for Undergraduate 201511810009the Hainan Medical College′s Training Project of Innovation and Entrepreneurship for Undergraduate HYCX2014015Natural Science Foundation of Hainan Province 20152040Supported by Natural Science Foundation of Hainan Province(No.20152040), the National Training Project of Innovation and Entrepreneurship for Undergraduate(No.201511810009), the Hainan Medical College′s Training Project of Innovation and Entrepreneurship for Undergraduate(No.HYCX2014015)

Figures(7)

Pyrazinedimethylformamide bridged apigenin copper(Ⅱ) complex was prepared by solvothermal method with 5, 6-dimethyl-2, 3-pyrazinedimethylformamide and apigenin as mixed ligands and copper(Ⅱ) acetate. The complex was characterized by ultra-violet and infrared spectroscopies, and thermogravimetric analysis. The DNA cleavage behavior of pyrazinedimethylformamide bridged apigenin copper(Ⅱ) complex has been investigated by agarose gel electrophoresis. The results suggest that the complex can promote the cleavage of pBR322 DNA in the absence of any reducing reagent.
- pyrazinedimethylformamide,
- apigenin,
- complex,
- synthesis,
- DNA cleavage activity
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