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Citation: . Phenylboronic Acid-Based Glucose-Sensitive Polymer Nanocarriers Used as Drug Delivery Systems[J]. Chinese Journal of Applied Chemistry, ;2017, 34(7): 733-743. doi: 10.11944/j.issn.1000-0518.2017.07.170035 shu

Phenylboronic Acid-Based Glucose-Sensitive Polymer Nanocarriers Used as Drug Delivery Systems

Received Date: 15 February 2017
Revised Date: 20 March 2017
Accepted Date: 20 April 2017

Fund Project: the National Natural Science Foundation of China 51390484the Scientific Development Program of Jilin Province 20140520050JHthe National Natural Science Foundation of China 51673190the National Natural Science Foundation of China 51303174the National Natural Science Foundation of China 51403075the Scientific Development Program of Jilin Province 20170520153JH

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Recently, the smart glucose-sensitive self-regulated drug delivery systems have attracted extensive attention. These smart drug delivery platforms can mimic the physiological model of pancreatic insulin secretion with a timely precise drug dose to control the blood glucose level effectively, and has broad application prospects in the treatment of diabetes. Phenylboronic acid(PBA)-functionalized glucose-sensitive polymer nanocarriers have been studied widely and have great stability, long term storability, and reversible glucose-sensitivity. According to response factors, there are pH-, temperature-, and light-responsive nanocarriers for glucose-sensitive drug delivery. This review covers the development, properties, and applications of glucose sensitive nanocarriers based on PBA, and the prospects are predicted.
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