Citation: LI Xiang, JIN Yingying, LIU Yibo, ZHAO Zhen, LI Xiao, CHENG Fang, LIU Zhonghua, HUANG Yongwei. Application and Progress of Perylenediimides Derivatives in Treating Tumor[J]. Chinese Journal of Applied Chemistry, ;2017, 34(6): 611-622. doi: 10.11944/j.issn.1000-0518.2017.06.160356 shu

Application and Progress of Perylenediimides Derivatives in Treating Tumor

LI Xiang ^a,b ,
JIN Yingying ^a,b ,
LIU Yibo ^a ,
ZHAO Zhen ^a ,
LI Xiao ^a ,
CHENG Fang ^a ,
LIU Zhonghua ^a,*,, ,
HUANG Yongwei ^a,*,,

a.
Laboratory for Medical Nanomaterials, School of Base Medical Science
b.
Huaihe Clinical Institute, Henan University, Kaifeng, Henan 475000, China

Corresponding author: LIU Zhonghua, lzh2001hawk@163.com HUANG Yongwei, hywei79@126.com
Received Date: 6 September 2016
Revised Date: 10 November 2017
Accepted Date: 17 January 2017

Fund Project: Project of Science and Technology Department of Henan Province 162102310074Program for Science & Technology Innovation Talents in the Universities of Henan Province 16HASTIT008China Postdoctoral Science Foundation 2015T80767Scientific Research Fund project of Henan University xxjc20140019China Postdoctoral Science Foundation 2013M530335the National Natural Science Foundation of China 21572045

Figures(7)

At present, malignant tumor has been becoming the main threat to human's death. Chemotherapy is one of the main methods of tumor therapy. However, there are many defects, such as side effects, drug resistance and difficulty of monitoring. Most of research works focus on improving the drugs' therapeutic effect and cutting down it's side effects, drugs' carriers are used to increase its concentration in the local lesions, which promote the efficiency of inhibiting tumor cells and reduce side effects with antitumor drugs. Perylenediimides derivatives(PDI) is a highly stable fluorescing materials, which is easily modified to enhance its biocompatibility and exercise a variety of functions. It can be used as drug carriers, fluorescence imaging, and anticancer drugs for cancers' diagnosis and treatment. This review focuses on the recent progress of PDI's biomedical applications and elaborates from drug carrier, antitumor drugs and fluorescent tracer aspects. This review summarized the basic experimental theory and gave the way for the application of PDI in clinical work.
- tumor,
- perylenediimides,
- nanocarriers,
- fluorescence image
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沈阳化工大学材料科学与工程学院沈阳 110142