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Citation: WU Jie, ZHANG Haijiang, YANG Guojun, WU Xiaochao. Removal of the Main Impurity from Benzafibrate by a Precipitation Method with Carbon Dioxide[J]. Chinese Journal of Applied Chemistry, ;2015, 32(9): 1088-1092. doi: 10.11944/j.issn.1000-0518.2015.09.150004 shu

Removal of the Main Impurity from Benzafibrate by a Precipitation Method with Carbon Dioxide

1.
a Department of Life Science and Chemical Engineering, Huaiyin Institute of Technology, Huaian, Jiangsu 223003, China;
2.
b Jiangsu Tasly Diyi Pharmaceutical Co. Ltd., Huaian, Jiangsu 223003, China

Corresponding author: WU Jie,
Received Date: 6 January 2015
Available Online: 14 April 2015
Fund Project: 江苏省科技厅产学研联合创新资金项目(BY2013052) (BY2013052)淮安市产学研合作促进计划项目(HC201207) (HC201207)

According to the acidicity difference between the main impurity and benzafibrate,carbon dioxide was introduced into the alkaline product solution to remove the impurity from benzafibrate in the post-treatment process.The yield and content of the treated products were determined to compare the separation effect with different methods of precipitation and recrystallization.Compared with recrystallization,the yield of the product treated with CO₂ was increased from 62.5% to 70.9%.The method not only reduced the relatively large solvent consumption and product loss caused by the repeated recrystallization,but also effectively improved the removal rate of impurities and decreased the separation cost.
- benzafibrate,
- carbon dioxide,
- precipitation,
- impurity
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