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Citation: XU Chang, AN Yue, ZHU Haotian, LIN Yue, WANG Rinan. Synthesis,Crystal Structure and Biological Activities of 3-Substituted-1-(5-aryl-1,3,4-thiadiazol-2-yl)-1H-pyrazole-4-formaldehyde[J]. Chinese Journal of Applied Chemistry, ;2015, 32(7): 748-758. doi: 10.11944/j.issn.1000-0518.2015.07.140421 shu

Synthesis,Crystal Structure and Biological Activities of 3-Substituted-1-(5-aryl-1,3,4-thiadiazol-2-yl)-1H-pyrazole-4-formaldehyde

1.
School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, Liaoning 116029, China

Corresponding author: AN Yue,
Received Date: 11 December 2014
Available Online: 6 March 2015
Fund Project: 辽宁省高等学校科学研究一般项目(L2014421)资助 (L2014421)

Sixteen title compounds 1,3,4-thiadiazole derivatives 5a~5p and sixteen intermediates 4a~4p were synthesized using 2-amino-5-substituted-1,3,4-thiadiazoles as the starting materials.All of thirty-two compounds are new compounds.The single crystal of compound 5a was obtained by solution crystallization method.X-ray single crystal diffraction analyses show that the crystal is a triclinic crystal system,P-1 space group.The structures of the title compounds and intermediates were characterized by IR,¹H NMR and elemental analyses.The antibacterial activity of compound 5 was evaluated with microdilution method.Compound 5h exhibits higher antibacterial activity to Staphylococcus aureus than the others,of which bacteriostasis rate is up to 65.30%.
- thiadiazole,
- pyrazole,
- synthesis,
- structure,
- biological activity
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