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Citation: XU Zhaohui. Sn O Catalyzed Solvent-Free Synthesis of Dimethyl 2-[(Indol-3-yl)-methyl] malonate Derivatives[J]. Chinese Journal of Applied Chemistry, ;2015, 32(7): 759-764. doi: 10.11944/j.issn.1000-0518.2015.07.140371 shu

Sn O Catalyzed Solvent-Free Synthesis of Dimethyl 2-[(Indol-3-yl)-methyl] malonate Derivatives

XU Zhaohui ^,

1.
Chemistry and Chemical Engineering Department, Jiangxi Normal University, Nanchang 330027, China

Corresponding author: XU Zhaohui,
Received Date: 30 October 2014
Available Online: 8 December 2014
Fund Project: 国家科技攻关计划(2001BA323C) (2001BA323C)江西省研究生创新基金(YC10A51)资助项目 (YC10A51)

Ten dimethyl 2-[(indol-3-yl)-methyl] malomate derivatives were synthesized by three-component one-pot reaction of indole with aldehydes and dimethyl malonate under solvent-free condition in the presence of Sn O as the catalyst.The yields ranged from 58% to 74%.The advantages of this method are no solvent pollution and mild reaction conditions.Furthermore,a mechanism for this condensation reaction was proposed and the relationship between reaction rate and substituent groups was also studied.All the compounds synthesized were confirmed by ¹ H NMR,¹³ C NMR and IR.
- dimethyl[(indol-yl)-methyl]malonate,
- dimethyl malonate,
- SnO,
- aldehydes,
- solvent-free
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