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Citation: QIAN Cunwei, HUANG Haijun, FEI Zhenghao, ZHANG Yuqing, WANG Dong, ZONG Qianshou. Synthesis and Bioactivity of New 1, 2, 4-Triazole Compounds Containing Thiazole and Thioether[J]. Chinese Journal of Applied Chemistry, ;2015, 32(4): 399-404. doi: 10.11944/j.issn.1000-0518.2015.04.140359 shu

Synthesis and Bioactivity of New 1, 2, 4-Triazole Compounds Containing Thiazole and Thioether

1.
a School of Chemistry and Chemical Engineering, Yancheng Teachers University, Yancheng, Jiangsu 224007, China;
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b Yancheng Limin Chemical Company Limited, Yancheng, Jiangsu 224005, China;
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c College of Biology and Chemical Engineering, Jiaxing University, Jiaxing, Zhejiang 314001, China

Corresponding author: QIAN Cunwei,
Received Date: 21 October 2014
Available Online: 12 February 2015
Fund Project: 2013年江苏省科技支撑(工业)项目基金(SBE201330457) (工业)项目基金(SBE201330457)江苏省高校自然科学基金(14JKD150009)资助 (14JKD150009)

Seven novel 1,2,4-triazole derivatives containing thioether and thiazole were designed and synthesized from ethyl 4,4,4-trifluoro-3-oxobutanoate, sulfonyl chloride, hydrazine hydrate, phenyl isothiocyanate,aryl iodides,chloroacetic acid as starting materials via substitution,hydrazinolysis,cyclization and Ullmann coupling. The structures of these compounds were characterized with¹³C NMR,¹H NMR,¹⁹F NMR and MS. Bactericidal activity test shows that Rhizoctoniasolani can be inhibited by compounds 6b,6d,and 6g at a concentration of 100 mg/L with inhibition rates of 91%,92% and 93%,respectively.
- thioether,
- thiazole,
- triazole,
- synthesis,
- bioactivity
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