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Citation: YANG Fengke, HAN Jian, WANG Yongchun, CHEN Fang. Synthesis and Biological Activity of Schiff Bases[J]. Chinese Journal of Applied Chemistry, ;2015, 32(4): 392-398. doi: 10.11944/j.issn.1000-0518.2015.04.140286 shu

Synthesis and Biological Activity of Schiff Bases

1.
College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, Shangdong 266042, China

Corresponding author: YANG Fengke,
Received Date: 14 August 2014
Available Online: 20 November 2014
Fund Project: 山东省自然科学基金资助项目(Q2006B02) (Q2006B02)

With raw materials of benzoyl chloride and p-bromophenol, mono-Schiff base, 2-[(2-aminophenylimino) phenylmethyl]-4-bromophenol,is obtained through multi-step reactions of esterification,Fries rearrangement and condensation. The mono-Schiff base reacts with aldehydes and ketones to give five asymmetric di-Schiff bases and two symmetric di-Schiff bases. These Schiff bases,particularly those containing sulfur atom in the molecule,show good antibacterial activities with a minimum inhibitory concentration of 1×10^-4g/L.
- Schiff base,
- synthesis,
- rearrangement,
- antibacterial activity
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