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Citation: ZHANG Yi, WU Lingbo, HU Qian, CHEN Baoxin, Wu Boyang, XUE Wei. Functionally Modified Hyperbranched Polyglycerols for Drug Delivery[J]. Chinese Journal of Applied Chemistry, ;2015, 32(4): 367-378. doi: 10.11944/j.issn.1000-0518.2015.04.140246 shu

Functionally Modified Hyperbranched Polyglycerols for Drug Delivery

1.
Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Ji'nan University, Guangzhou 510632, China

Corresponding author: XUE Wei,
Received Date: 16 July 2014
Available Online: 20 November 2014
Fund Project: 国家自然科学基金项目(81101151,31271019) (81101151,31271019)

Polymeric nanocarriers with controllable drug realease and stimuli-responsive to targeted biological conditions are an advancing and potential carrier candidate for nanomedicines. Hyperbranched polyglycerols(HPG) spur the interest of the biomaterial community due to their well-defined three-dimensional structures,good solubility,high biocompatiblity and multiple attachment sites for modification. Functionally modified HPG derivatives are able to self-assemble into a variety of drug carriers such as micelles and vesicles. Herein,we present the current progress on functional modified HPG for drug delivery with particular focus on amphiphilic modification, stimuli-responsive functionalization, as well as supra molecular self-assembly.Molecular design strategy for HPG modification with amphiphilic and stimuli responsive functionalization is systematically summarized. Furthermore,the assembly behavior of hyperbranched supra molecular polyglycerol copolymers based on cyclodextrin host-guest interactions is also mentioned.
- hyperbranched polyglycerol,
- drug delivery,
- amphiphilic modification,
- stimuli responsive,
- supra molecular self-assembl
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