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Citation: CHEN Yong, WU Hankui, LONG Junfei. Synthesis and Antifungal Activity of Novel Azole Derivatives with 2',4'-Dihalobiphenyl[J]. Chinese Journal of Applied Chemistry, ;2015, 32(1): 43-52. doi: 10.11944/j.issn.1000-0518.2015.01.140094 shu

Synthesis and Antifungal Activity of Novel Azole Derivatives with 2',4'-Dihalobiphenyl

1.
Chemistry & Chemical Industry School, Anyang Normal University, Anyang, He'nan 455000, China

Corresponding author: CHEN Yong,
Received Date: 25 March 2014
Available Online: 11 July 2014
Fund Project: 河南省科技攻关立项课题(122102310520) (122102310520)安阳市科技攻关立项课题(编号:20) (编号:20)

Novel azole title compounds with 2',4'-dihalobiphenyl 3a~3k were synthesized via F-C acylation, reduction and substitution reactions starting from 2,4-dihalobiphenyl. The structures of these compounds were confirmed by IR,¹H NMR,¹³C NMR and HMRS spectra. In vitro antifungal activities of title compounds were evaluated. The results of preliminary biological tests show that the title compounds exhibit antifungal activities against to tested pathogenic fungi to some extent. Antifungal activities against to Trichophyton rubrum and Trichophyton mentagrophytes of compounds 3a~3k were equivalent to that of Amphotericin B. Antifungal activities of compounds 3b,3c,3e,3f,3h,3i,3k against to Candiada albicans were higher than that of ketoconazole.
- dihalobiphenyl,
- synthesis,
- novel azole derivatives,
- antifungal activity
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