Citation: JIA Yong-Mei, LOU Xiao-Ding, XIA Fan. Fluorescent Bioprobe Based on Nucleic Acid for Live Cell Imaging[J]. Chinese Journal of Analytical Chemistry, ;2018, 46(9): 1329-1338. doi: 10.11895/j.issn.0253-3820.181340 shu

Fluorescent Bioprobe Based on Nucleic Acid for Live Cell Imaging

1.
School of Chemistry and Chemical Engineering, Lingnan Normal University, Zhanjiang 524048, China;
2.
Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan 430074, China;
3.
School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China

Received Date: 21 May 2018
Revised Date: 11 July 2018

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 201705071), the Natural Science Foundation of Gugangdong Province, China (No. 2016A030310362), and the Initiatory Financial Support from Lingnan Normal University (No. ZL1611).

Live cell imaging is an essential tool for detecting intracellular biomolecules, particularly those that are key targets in disease processes and monitoring their functions in live cells. Usually, the intracellular biomolecules cannot make out signal change that could be detected by instrument or naked eye directly. Thus, target identification and validation with high-affinity probes is one of the key prerequisites for interrogation of specific molecular targets in living systems. There are many kinds of bioprobes. Among them, fluorescent bioprobes based on nucleic acids are essential tools due to their high sensitivity, fast response, simplicity, real-time, on-site and non-invasive visualization of biological molecules and processes in live cells. They not only provide valuable insight in understanding physiological alterations in pathological settings but also serve as useful tools for the development of personalized medicine and targeted therapies. This review summarizes the progress of fluorescent bioprobes based on nucleic acids for live cell imaging in recent 5 years.
- Fuorescent bioprobe,
- Cell imaging,
- Biosensor,
- Molecular detection,
- Review
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