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Citation: HAN Xian-Wei, ZHANG Hong-Wu, LUO Hong-Yan, ZHENG Xiao-Lin, YANG Zhong, HU Ning, LIAO Yan-Jian, YANG Jun. Preparation of Poly (vinyl alcohol) Microspheres Based on Droplet Microfluidic Technology[J]. Chinese Journal of Analytical Chemistry, ;2018, 46(8): 1269-1274. doi: 10.11895/j.issn.0253-3820.181156 shu

Preparation of Poly (vinyl alcohol) Microspheres Based on Droplet Microfluidic Technology

1.
Key Laboratory of Biorheological Science and Technology, Chongqing University, Ministry of Education, and Key Lab of Visual Damage and Regeneration & Restoration of Chongqing, Bioengineering College, Chongqing University, Chongqing 400030, China;
2.
School of Economics and Business Administration, Chongqing University, Chongqing 400030, China;
3.
Department of Laboratory Medicine, Southwest Hospital, Third Military Medical University, Chongqing 400038, China

Received Date: 13 March 2018
Revised Date: 5 June 2018

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 81501617), the National International Science and Technology Cooperation Project (No. 2014DFG31380) and the "Student Technology Innovation Fund" Project of the Central University's Basic Research Business Fee (No. CDJXS11230046).

A new method is used to prepare poly(vinyl alcohol) (PVA) microspheres. Droplet formation technology can produce a large number of uniform scale and monodisperse PVA droplets on the microfluidic chip quickly and continuously, and the droplet preparation speed can reach 6/sec. The size of the PVA droplets can be controlled by changing the injection flow rate of the two-phase fluid and the width of microfluidic channel. Then the PVA microspheres are formed by physical crosslinking. This method has high preparation efficiency and good monodisperse effect of the obtained microspheres. Moreover, the process does not require the incorporation of chemical crosslinking agents, avoiding interference with the inclusion material, and is well suited for applications such as drug carrier.
- Poly(vinyl alcohol),
- Microfluidic chip,
- Droplets,
- Physical crosslinking,
- Poly (vinyl alcohol) microspheres
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1.
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