Citation: XU Lin-Nan, BAI Yu, LIU Hu-Wei. Research Progresses in Phosphopeptide Enrichment[J]. Chinese Journal of Analytical Chemistry, ;2017, 45(12): 1804-1812. doi: 10.11895/j.issn.0253-3820.171338 shu

Research Progresses in Phosphopeptide Enrichment

Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China

Corresponding author: BAI Yu, yu.bai@pku.edu.cn
Received Date: 16 October 2017
Accepted Date: 8 November 2017

Fund Project: the National Natural Science Foundation of China 21527809the National Natural Science Foundation of China 21575007the National Natural Science Foundation of China 21322505This work was supported by the National Natural Science Foundation of China (Nos. 21575007, 21527809, 21322505)

Figures(2)

Phosphopeptide enrichment is of great significance in phosphoproteomics related research. Pre-analysis enrichment helps concentrating phosphopeptides of low abundance, and other interferences of high abundance, such as non-phosphorylated peptides, will be eliminated at the same time. By this way, the enhanced sensitivity of mass-spectrometry analysis of phosphopeptides can be achieved, as well as better detection and identification performance. The key for phosphopeptide enrichment is enrichment materials with specific affinity towards phosphopeptides. Enrichment materials with different phosphopeptide adsorption mechanisms have been developed, while various improvements on material morphologies, enrichment operation, and enrichment specificity are also reported. In the review, we summarized recent progresses in phosphopeptide enrichment from perspectives of both enrichment materials with different enrichment mechanisms, and improvement on methodologies of phosphopeptide enrichment based on various enrichment materials.
- Phosphopeptide,
- Sample preparation,
- Enrichment,
- Mass spectrometry,
- Review
1. [1]
  Hunter T. Cell, 1995, 80(2):225-236 doi: 10.1016/0092-8674(95)90405-0
2. [2]
  Duan D, Chai G, Ni Z, Hu Y, Luo Y, Cheng X, Chen N, Wang J, Liu G. J. Alzheimers Dis., 2013, 37(4):795-808
3. [3]
  Wagner E F, Nebreda A R. Nat. Rev. Cancer, 2009, 9(8):537-549 doi: 10.1038/nrc2694
4. [4]
  Hammarsten P, Karalija A, Josefsson A, Rudolfsson S H, Wikstrom P, Egevad L, Granfors T, Stattin P, Bergh A. Clin. Cancer Res., 2010, 16(4):1245-1255 doi: 10.1158/1078-0432.CCR-09-0103
5. [5]
  Heemskerk A A M, Busnel J-M, Schoenmaker B, Derks R J E, Klychnikov O, Hensbergen P J, Deelder A M, Mayboroda O A. Anal. Chem., 2012, 84(10):4552-4559 doi: 10.1021/ac300641x
6. [6]
  Annesley T M. Clin. Chem., 2003, 49(7):1041-1044 doi: 10.1373/49.7.1041
7. [7]
  Ahn Y H, Ji E S, Lee J Y, Cho K, Yoo J S. Rapid Commun. Mass. Spectrom., 2007, 21(24):3987-3994 doi: 10.1002/(ISSN)1097-0231
8. [8]
  Li H, Sundararajan N. J. Proteome Res., 2007, 6(8):2973-2977 doi: 10.1021/pr0606225
9. [9]
  Boersema P J, Foong L Y, Ding V M Y, Lemeer S, van Breukelen B, Philp R, Boekhorst J, Snel B, den Hertog J, Choo A B H, Heck A J R. Mol. Cell. Proteomics, 2010, 9(1):84-99 doi: 10.1074/mcp.M900291-MCP200
10. [10]
  Zoumaro-Djayoon A D, Heck A J R, Munoz J. Methods, 2012, 56(2):268-274 doi: 10.1016/j.ymeth.2011.09.003
11. [11]
  Bian Y, Li L, Dong M, Liu X, Kaneko T, Cheng K, Liu H, Voss C, Cao X, Wang Y, Litchfield D, Ye M, Li S S C, Zou H. Nat. Chem. Biol., 2016, 12(11):959-966 doi: 10.1038/nchembio.2178
12. [12]
  Liu B A, Shah E, Jablonowski K, Stergachis A, Engelmann B, Nash P D. Sci. Signal., 2011, 4(202):ra83
13. [13]
  Emgenbroich M, Borrelli C, Shinde S, Lazraq I, Vilela F, Hall A J, Oxelbark J, De Lorenzi E, Courtois J, Simanova A, Verhage J, Irgum K, Karim K, Sellergren B. Chem. Eur. J., 2008, 14(31):9516-9529 doi: 10.1002/chem.v14:31
14. [14]
  Chen J, Shinde S, Subedi P, Wierzbicka C, Sellergren B, Helling S, Marcus K. J. Chromatogr. A, 2016, 1471:45-50 doi: 10.1016/j.chroma.2016.10.018
15. [15]
  Li Q, Shen F, Zhang X, Hu Y, Zhang Q, Xu L, Ren X. Anal. Chim. Acta, 2013, 795:82-87 doi: 10.1016/j.aca.2013.07.040
16. [16]
  Zou X, Liu D, Zhong L, Yang B, Lou Y, Hu B, Yin Y. Anal. Bioanal. Chem., 2011, 401(4):1251-1261 doi: 10.1007/s00216-011-5186-x
17. [17]
  Ye J, Zhang X, Young C, Zhao X, Hao Q, Cheng L, Jensen O N. J. Proteome Res., 2010, 9(7):3561-3573 doi: 10.1021/pr100075x
18. [18]
  Lu J, Li Y, Deng C. Nanoscale, 2011, 3(3):1225-1233 doi: 10.1039/c0nr00896f
19. [19]
  Li X, Xu L, Zhu G, Yuan B, Feng Y. Analyst, 2012, 137(4):959-967 doi: 10.1039/C2AN15985F
20. [20]
  Zhang L, Zhao Q, Liang Z, Yang K, Sun L, Zhang L, Zhang Y. Chem. Commun., 2012, 48(50):6274-6276 doi: 10.1039/c2cc31641b
21. [21]
  Piovesana S, Capriotti A L, Cavaliere C, Ferraris F, Samperi R, Ventura S, Lagana A. Anal. Chim. Acta, 2016, 909:67-74 doi: 10.1016/j.aca.2016.01.008
22. [22]
  Saeed A, Maya F, Xiao D J, Najam-ul-Haq M, Svec F, Britt D K. Adv. Funct. Mater., 2014, 24(37):5790-5797 doi: 10.1002/adfm.201400116
23. [23]
  Biswas S, Sarkar A, Misra R. Biotechnol. Biotec. Eq., 2017, 31(3):639-646 doi: 10.1080/13102818.2017.1293492
24. [24]
  Ruprecht B, Koch H, Medard G, Mundt M, Kuster B, Lemeer S. Mol. Cell. Proteomics, 2015, 14(1):205-215 doi: 10.1074/mcp.M114.043109
25. [25]
  Xiong Z, Zhang L, Fang C, Zhang Q, Ji Y, Zhang Z, Zhang W, Zou H. J. Mater. Chem. B, 2014, 2(28):4473-4480 doi: 10.1039/C4TB00479E
26. [26]
  Zhou H, Ye M, Dong J, Han G, Jiang X, Wu R, Zou H. J. Proteome Res., 2008, 7(9):3957-3967 doi: 10.1021/pr800223m
27. [27]
  Wei X, Shi X. J. Phys. Chem. C, 2014, 118(8):4213-4221 doi: 10.1021/jp411346k
28. [28]
  Zheng L, Dong H, Hu L. Ind. Eng. Chem. Res., 2013, 52(23):7729-7736 doi: 10.1021/ie4003377
29. [29]
  Lai A C Y, Tsai C F, Hsu C C, Sun Y N, Chen Y J. Rapid Commun. Mass. Spectrom., 2012, 26(18):2186-2194 doi: 10.1002/rcm.v26.18
30. [30]
  Tsai C F, Hsu C C, Hung J N, Wang Y T, Choong W K, Zeng M Y, Lin P Y, Hong R W, Sung T Y, Chen Y J. Anal. Chem., 2014, 86(1):685-693 doi: 10.1021/ac4031175
31. [31]
  Xie Y, Deng C. Talanta, 2016, 159:1-6 doi: 10.1016/j.talanta.2016.05.075
32. [32]
  Chen Y, Xiong Z, Peng L, Gan Y, Zhao Y, Shen J, Qian J, Zhang L, Zhang W. ACS Appl. Mater. Interfaces, 2015, 7(30):16338-16347 doi: 10.1021/acsami.5b03335
33. [33]
  Li D, Bie Z. RSC Adv., 2017, 7(26):15894-15902 doi: 10.1039/C7RA00263G
34. [34]
  Xie Y, Deng C. Sci. Rep., 2017, 7:1162 doi: 10.1038/s41598-017-01341-y
35. [35]
  Qi X, Chang C, Xu X, Zhang Y, Bai Y, Liu H. J. Chromatogr. A, 2016, 1468:49-54 doi: 10.1016/j.chroma.2016.09.046
36. [36]
  Wang H, Jiao F, Gao F, Lyu Y, Wu Q, Zhao Y, Shen Y, Zhang Y, Qian X. Talanta, 2017, 166:133-140 doi: 10.1016/j.talanta.2017.01.043
37. [37]
  Pinkse M W H, Uitto P M, Hilhorst M J, Ooms B, Heck A J R. Anal. Chem., 2004, 76(14):3935-3943
38. [38]
  Sano A, Nakamura H. Anal. Sci., 2004, 20(3):565-566 doi: 10.2116/analsci.20.565
39. [39]
  Huang X, Wang J, Liu C, Guo T, Wang S. J. Mater. Chem. B, 2015, 3(12):2505-2515 doi: 10.1039/C4TB01899K
40. [40]
  Yue X, Schunter A, Hummon A B. Anal. Chem., 2015, 87(17):8837-8844 doi: 10.1021/acs.analchem.5b01833
41. [41]
  Ma W, Zhang F, Li L, Chen S, Qi L, Liu H, Bai Y. ACS Appl. Mater. Interfaces, 2016, 8(51):35099-35105 doi: 10.1021/acsami.6b14597
42. [42]
  Zhao D, He Z, Wang G, Wang H, Zhang Q, Li Y. J. Colloid Interface Sci., 2016, 478:227-235 doi: 10.1016/j.jcis.2016.05.054
43. [43]
  Long X, Li J, Sheng D, Lian H. RSC Adv., 2016, 6(98):96210-96222 doi: 10.1039/C6RA11125D
44. [44]
  Jabeen F, Hussain D, Fatima B, Musharraf S G, Huck C W, Bonn G K, Najam-ul-Haq M. Anal. Chem., 2012, 84(23):10180-10185 doi: 10.1021/ac3023197
45. [45]
  Aryal U K, Ross A R S. Rapid Commun. Mass. Spectrom., 2010, 24(2):219-231 doi: 10.1002/rcm.v24:2
46. [46]
  Kweon H K, Hakansson K. Anal. Chem., 2006, 78(6):1743-1749 doi: 10.1021/ac0522355
47. [47]
  Li L, Zheng T, Xu L, Li Z, Sun L, Nie Z, Bai Y, Liu H. Chem. Commun., 2013, 49(17):1762-1764 doi: 10.1039/c3cc38909j
48. [48]
  Sun S, Ma H, Han G, Wu R a, Zou H, Liu Y. Rapid Commun. Mass. Spectrom., 2011, 25(13):1862-1868 doi: 10.1002/rcm.5055
49. [49]
  Zhong H, Xiao X, Zheng S, Zhang W, Ding M, Jiang H, Huang L, Kang J. Nat. Commun., 2013, 4:1656 doi: 10.1038/ncomms2662
50. [50]
  Wang M, Deng C, Li Y, Zhang X. ACS Appl. Mater. Interfaces, 2014, 6(14):11775-11782 doi: 10.1021/am502530c
51. [51]
  Li X, Chen X, Sun H, Yuan B, Feng Y. J. Chromatogr. A, 2015, 1376:143-148 doi: 10.1016/j.chroma.2014.12.036
52. [52]
  Qi X, Chen L, Zhang C, Xu X, Zhang Y, Bai Y, Liu H. ACS Appl. Mater. Interfaces, 2016, 8(29):18675-18683 doi: 10.1021/acsami.6b04280
53. [53]
  Sun X, Jiang X. Anal. Bioanal. Chem., 2017, 409(9):2489-2493 doi: 10.1007/s00216-017-0198-9
54. [54]
  Dong M, Wu M, Wang F, Qin H, Han G, Gong J, Wu R A, Ye M, Liu Z, Zou H. Anal. Chem., 2010, 82(7):2907-2915 doi: 10.1021/ac902907w
55. [55]
  Chang C K, Wu C C, Wang Y S, Chang H C. Anal. Chem., 2008, 80(10):3791-3797 doi: 10.1021/ac702618h
56. [56]
  Xu L, Li L, Jin L, Bai Y, Liu H. Chem. Commun., 2014, 50(75):10963-10966 doi: 10.1039/C4CC04327H
57. [57]
  Xu L, Ma W, Shen S, Li L, Bai Y, Liu H. Chem. Commun., 2016, 52(6):1162-1165 doi: 10.1039/C5CC07941A
58. [58]
  Alpert A J, Hudecz O, Mechtler K. Anal. Chem., 2015, 87(9):4704-4711 doi: 10.1021/ac504420c
59. [59]
  Zhou H L, Watts J D, Aebersold R. Nat. Biotechnol., 2001, 19(4):375-378 doi: 10.1038/86777
60. [60]
  McLachlin D T, Chait B T. Anal. Chem., 2003, 75(24):6826-6836 doi: 10.1021/ac034989u
61. [61]
  Batalha I L, Roque A C A, Phosphopeptide Enrichment Using Various Magnetic Nanocomposites:An Overview, in Phospho-Proteomics:Methods, Protocols, 2nd Edition, ed. L. VonStechow, 2016, 1355:193-209
62. [62]
  Salimi K, Usta D D, Celikbicak O, Pinar A, Salih B, Tuncel A. Colloids Surf. B, 2017, 153:280-290 doi: 10.1016/j.colsurfb.2017.02.028
63. [63]
  Zhao Y, Zhang L, Chu Z, Xiong Z, Zhang W. Anal. Methods, 2017, 9(3):443-449 doi: 10.1039/C6AY02905A
64. [64]
  Lu Z, Duan J, He L, Hu Y, Yin Y. Anal. Chem., 2010, 82(17):7249-7258 doi: 10.1021/ac1011206
65. [65]
  Zhang Y, Li L, Ma W, Zhang Y, Yu M, Guo J, Lu H, Wang C. ACS Appl. Mater. Interfaces, 2013, 5(3):614-621 doi: 10.1021/am3019806
66. [66]
  Yao J, Sun N, Wang J, Xie Y, Deng C, Zhang X. Proteomics, 2017, 17(8):UNSP1600320 doi: 10.1002/pmic.v17.8
67. [67]
  Shi C, Deng C. Talanta, 2015, 143:464-468 doi: 10.1016/j.talanta.2015.05.039
68. [68]
  Zhu G, He X, He S, Chen X, Zhu S, Feng Y. ACS Appl. Mater. Interfaces, 2016, 8(47):32182-32188 doi: 10.1021/acsami.6b10948
69. [69]
  Krenkova J, Foret F. Anal. Bioanal. Chem., 2013, 405(7):2175-2183 doi: 10.1007/s00216-012-6358-z
70. [70]
  Liu F, Wan H, Liu Z, Wang H, Mao J, Ye M, Zou H. Anal. Chem., 2016, 88(10):5058-5064 doi: 10.1021/acs.analchem.6b00701
71. [71]
  Yang H, Deng C, Zhang X. Talanta, 2016, 153:285-294 doi: 10.1016/j.talanta.2016.03.012
72. [72]
  Mohammed S, Kraiczek K, Pinkse M W H, Lemeer S, Benschop J J, Heck A J R. J. Proteome Res., 2008, 7(4):1565-1571
73. [73]
  Araya-Farias M, Dziomba S, Carbonnier B, Guerrouache M, Ayed I, Aboud N, Taverna M, Tran N T. Analyst, 2017, 142(3):485-494 doi: 10.1039/C6AN02324J
74. [74]
  Krasny L, Pompach P, Strnadova M, Hynek R, Valis K, Havlicek V, Novak P, Volny M. J. Mass Spectrom., 2015, 50(6):802-811 doi: 10.1002/jms.3586
75. [75]
  Wang H, Duan J, Cheng Q. Anal. Chem., 2011, 83(5):1624-1631 doi: 10.1021/ac1024232
76. [76]
  Shi C, Lin Q, Deng C. Talanta, 2015, 135:81-86 doi: 10.1016/j.talanta.2014.12.041
77. [77]
  Lin H, Yuan K, Deng C. Talanta, 2017, 175:427-434 doi: 10.1016/j.talanta.2017.07.078
78. [78]
  Wu T, Shi J, Zhang C, Zhang L, Du Y. J. Chromatogr. B, 2016, 1008:234-239 doi: 10.1016/j.jchromb.2015.11.051
79. [79]
  Abelin J G, Trantham P D, Penny S A, Patterson A M, Ward S T, Hildebr, W H, Cobbold M, Bai D L, Shabanowitz J, Hunt D F. Nat. Protoc.,2015,10(9):1308-1318 doi: 10.1038/nprot.2015.086
80. [80]
  Palika R, Mashurabad P C, Nair M K, Reddy G B, Pullakhandam R. Food Res. Int., 2015, 67:308-314 doi: 10.1016/j.foodres.2014.11.049
81. [81]
  Leitner A, Enrichment Strategies in Phosphoproteomics, in Phospho-Proteomics:Methods, Protocols, 2nd Edition, ed. L. VonStechow, 2016, 1355:105-121
82. [82]
  Shiau K J, Hung S U, Lee H W, Wu C C. Analyst, 2011, 136(9):1922-1927 doi: 10.1039/c0an01046d
1. [1]
  Zunxiang Zeng , Yuling Hu , Yufei Hu , Hua Xiao . Analysis of Plant Essential Oils by Supercritical CO₂Extraction with Gas Chromatography-Mass Spectrometry: An Instrumental Analysis Comprehensive Experiment Teaching Reform. University Chemistry, 2024, 39(3): 274-282. doi: 10.3866/PKU.DXHX202309069
2. [2]
  Zufeng Qiu , Jie Ouyang , Yiru Wang , Hengting Yang , Xin Liao , Chi Zhang , Xuanyao Jiang , Shunliu Deng , Zhiwei Lin . 综合运用分析仪器解析“盲盒”样品——未知物的剖析. University Chemistry, 2025, 40(6): 296-302. doi: 10.12461/PKU.DXHX202405167
3. [3]
  Jingyi Chen , Fu Liu , Tiejun Zhu , Kui Cheng . Practice of Integrating Ideological and Political Education into Raman Spectroscopy Analysis Experiment Course. University Chemistry, 2024, 39(2): 140-146. doi: 10.3866/PKU.DXHX202310111
4. [4]
  Xin Hua , Songqin Liu . Research on Teaching Practice of Spectral Analytical Chemistry Based on Thematic Discussion. University Chemistry, 2025, 40(7): 106-111. doi: 10.12461/PKU.DXHX202408043
5. [5]
  Zian Lin , Yingxue Jin . Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry (MALDI-MS) for Disease Marker Screening and Identification: A Comprehensive Experiment Teaching Reform in Instrumental Analysis. University Chemistry, 2024, 39(11): 327-334. doi: 10.12461/PKU.DXHX202403066
6. [6]
  Fa Wang , Yu Chen , Hui Chao . Ruthenium(II) Complexes as Photoactivated Chemo-Prodrugs for Hypoxic Tumor Therapy. University Chemistry, 2025, 40(7): 200-212. doi: 10.12461/PKU.DXHX202410024
7. [7]
  Jing Wang , Pingping Li , Yuehui Wang , Yifan Xiu , Bingqian Zhang , Shuwen Wang , Hongtao Gao . Treatment and Discharge Evaluation of Phosphorus-Containing Wastewater. University Chemistry, 2024, 39(5): 52-62. doi: 10.3866/PKU.DXHX202309097
8. [8]
  Zhongyan Cao , Shengnan Jin , Yuxia Wang , Yiyi Chen , Xianqiang Kong , Yuanqing Xu . Advances in Highly Selective Reactions Involving Phenol Derivatives as Aryl Radical Precursors. University Chemistry, 2025, 40(4): 245-252. doi: 10.12461/PKU.DXHX202405186
9. [9]
  Zhaohu Li , Weidong Wang , Yuhao Liu , Mingzhe Han , Lingling Wei , Huan Jiao . Research on the Safety Management and Disposal of Chemical Laboratory Waste. University Chemistry, 2024, 39(10): 128-136. doi: 10.3866/PKU.DXHX202312090
10. [10]
  Zehua Zhao , Xiaoyan An , Jinrong Xu , Ling Yang , Hao Zhao , Zhongyun Wu . Independent Development and Application of Calorimetric Experiment Data Acquisition and Processing Software. University Chemistry, 2025, 40(11): 402-408. doi: 10.12461/PKU.DXHX202505045
11. [11]
  Xiaofei Liu , He Wang , Li Tao , Weimin Ren , Xiaobing Lu , Wenzhen Zhang . Electrocarboxylation of Benzylic Phosphates and Phosphinates with Carbon Dioxide. Acta Physico-Chimica Sinica, 2024, 40(9): 2307008-0. doi: 10.3866/PKU.WHXB202307008
12. [12]
  Lisen Sun , Yongmei Hao , Zhen Huang , Yongmei Liu . Experimental Teaching Design for Viscosity Measurement Serves the Optimization of Operating Conditions for Kitchen Waste Treatment Equipment. University Chemistry, 2024, 39(2): 52-56. doi: 10.3866/PKU.DXHX202307063
13. [13]
  Kun Xu , Xinxin Song , Zhilei Yin , Jian Yang , Qisheng Song . Comprehensive Experimental Design of Preferential Orientation of Zinc Metal by Heat Treatment for Enhanced Electrochemical Performance. University Chemistry, 2024, 39(4): 192-197. doi: 10.3866/PKU.DXHX202309050
14. [14]
  Hanmei Lü , Xin Chen , Qifu Sun , Ning Zhao , Xiangxin Guo . Uniform Garnet Nanoparticle Dispersion in Composite Polymer Electrolytes. Acta Physico-Chimica Sinica, 2024, 40(3): 2305016-0. doi: 10.3866/PKU.WHXB202305016
15. [15]
  Xianyong Lu , Tao Hu . Developing an Innovative Inorganic Chemistry Teaching Model Based on Aerospace Specialty Characteristics. University Chemistry, 2025, 40(7): 127-131. doi: 10.12461/PKU.DXHX202409037
16. [16]
  Xinran Zhang , Siqi Liu , Yichi Chen , Qingli Zou , Qinghong Xu , Yaqin Huang . From Protein to Energy Storage Materials: Edible Gelatin Jelly Electrolyte. University Chemistry, 2025, 40(7): 255-266. doi: 10.12461/PKU.DXHX202408104
17. [17]
  Yan Zhang , Xiaoyan Cao , Yiming Li , Shuwei Xia , Mutai Bao . Comparison of Electrolyte Solutions Section in Physical Chemistry Textbooks at Home and Abroad. University Chemistry, 2025, 40(9): 303-309. doi: 10.12461/PKU.DXHX202502027
18. [18]
  Jiandong Liu , Zhijia Zhang , Kamenskii Mikhail , Volkov Filipp , Eliseeva Svetlana , Jianmin Ma . Research Progress on Cathode Electrolyte Interphase in High-Voltage Lithium Batteries. Acta Physico-Chimica Sinica, 2025, 41(2): 100011-0. doi: 10.3866/PKU.WHXB202308048
19. [19]
  Chunai Dai , Yongsheng Han , Luting Yan , Zhen Li , Yingze Cao . Preparation of Superhydrophobic Surfaces and Their Application in Oily Wastewater Treatment: Design of a Comprehensive Physical Chemistry Innovation Experiment. University Chemistry, 2024, 39(2): 34-40. doi: 10.3866/PKU.DXHX202307081
20. [20]
  Zhangshu Wang , Xin Zhang , Jixin Han , Xuebing Fang , Xiufeng Zhao , Zeyu Gu , Jinjun Deng . Exploration and Design of Experimental Teaching on Ultrasonic-Enhanced Synergistic Treatment of Ternary Composite Flooding Produced Water. University Chemistry, 2024, 39(5): 116-124. doi: 10.3866/PKU.DXHX202310056

Get Citation

PDF

XML

Metrics

PDF Downloads(12)
Abstract views(1779)
HTML views(290)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142