Citation: SUN Gong-Wei, HONG Wei-Zhe, ZHANG Yu-Qing, HU Zhi-An, XING Zhi, ZHANG Si-Chun, ZHANG Xin-Rong. Development of Multiplex Immunoassay Based on Inductively Coupled Plasma Mass Spectrometry[J]. Chinese Journal of Analytical Chemistry, ;2017, 45(12): 1786-1794. doi: 10.11895/j.issn.0253-3820.171324 shu

Development of Multiplex Immunoassay Based on Inductively Coupled Plasma Mass Spectrometry

Department of Chemistry, Tsinghua University, Beijing 100084, China

Corresponding author: ZHANG Xin-Rong, xrzhang@mail.tsinghua.edu.cn
Received Date: 12 October 2017
Accepted Date: 4 November 2017

Fund Project: the National Natural Science Foundation of China 21621003This work was supported by the National Natural Science Foundation of China (Nos. 21390410, 21621003)the National Natural Science Foundation of China 21390410

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Immunoassay is of great importance in the field of clinical detection. Our group proposes the inductively coupled plasma mass spectrometry (ICP-MS) based immunoassay. Multiplex immunoassay can be realized by stable isotope tagging strategy combined with ICP-MS detection. Since then, large amount of researches in this field have been made at home and abroad, and the method has been proved applicable to the analysis of biological small molecules, proteins, nucleic acids and cells. In this article, the history and development of immunoassay, the characters of ICP-MS based immunoassay, single component and multiplex immunoassay, and the magnetic immunoassay that is recently fast developed are reviewed. The prospect of the developing tendency is also anticipated, hoping to provide references for the research in this field.
- Immunoassay,
- Inductively coupled plasma mass spectrometry,
- Multiplex immunoassay,
- Review
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