Citation: SUN Gong-Wei, HONG Wei-Zhe, ZHANG Yu-Qing, HU Zhi-An, XING Zhi, ZHANG Si-Chun, ZHANG Xin-Rong. Development of Multiplex Immunoassay Based on Inductively Coupled Plasma Mass Spectrometry[J]. Chinese Journal of Analytical Chemistry, ;2017, 45(12): 1786-1794. doi: 10.11895/j.issn.0253-3820.171324 shu

Development of Multiplex Immunoassay Based on Inductively Coupled Plasma Mass Spectrometry

Department of Chemistry, Tsinghua University, Beijing 100084, China

Corresponding author: ZHANG Xin-Rong, xrzhang@mail.tsinghua.edu.cn
Received Date: 12 October 2017
Accepted Date: 4 November 2017

Fund Project: the National Natural Science Foundation of China 21621003This work was supported by the National Natural Science Foundation of China (Nos. 21390410, 21621003)the National Natural Science Foundation of China 21390410

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Immunoassay is of great importance in the field of clinical detection. Our group proposes the inductively coupled plasma mass spectrometry (ICP-MS) based immunoassay. Multiplex immunoassay can be realized by stable isotope tagging strategy combined with ICP-MS detection. Since then, large amount of researches in this field have been made at home and abroad, and the method has been proved applicable to the analysis of biological small molecules, proteins, nucleic acids and cells. In this article, the history and development of immunoassay, the characters of ICP-MS based immunoassay, single component and multiplex immunoassay, and the magnetic immunoassay that is recently fast developed are reviewed. The prospect of the developing tendency is also anticipated, hoping to provide references for the research in this field.
- Immunoassay,
- Inductively coupled plasma mass spectrometry,
- Multiplex immunoassay,
- Review
1. [1]
  Hage D S. Anal. Chem., 1995, 67(12):R455-R462 doi: 10.1021/ac00108a030
2. [2]
  Hagan A K, Zuchner T. Anal. Bioanal. Chem., 2011, 400(9):2847-2864 doi: 10.1007/s00216-011-5047-7
3. [3]
  Jackson T M, Ekins R P. J. Immunol. Methods., 1986, 87(1):13-20 doi: 10.1016/0022-1759(86)90338-8
4. [4]
  Liu R, Wu P, Yang L, Hou X, Lyu Y. Mass Spectrom. Rev., 2014, 33(5):373-393 doi: 10.1002/mas.v33.5
5. [5]
  Yalow R S, Berson S A. Nature, 1959, 184(4699):1648-1649
6. [6]
  Lequin R M. Clin. Chem., 2005, 51(12):2415-2418 doi: 10.1373/clinchem.2005.051532
7. [7]
  Engvall E, Perlmann P. J. Immunoass. Immunoch., 1971, 8(9):871-875 doi: 10.1016/0019-2791(71)90454-X
8. [8]
  Schroeder H R, Vogelhut P O, Carrico R J, Bogulaski R C, Buckler R T. Anal. Chem., 1976, 48(13):1933-1937 doi: 10.1021/ac50007a032
9. [9]
  Zhao L, Sun L, Chu X. TrAC-Trends Anal. Chem., 2009, 28(4):404-415 doi: 10.1016/j.trac.2008.12.006
10. [10]
  Soini E, Hemmila I. Clin. Chem., 1979, 25(3):353-361
11. [11]
  Blackburn G F, Shah H P, Kenten J H, Leland J, Kamin R A, Link J, Peterman J, Powell M J, Shah A, Talley D B, Tyagi S K, Wilkins E, Wu T G, Massey R J. Clin. Chem., 1991, 37(9):1534-1539
12. [12]
  Kenten J H, Casadei J, Link J, Lupold S, Willey J, Powell M, Rees A, Massey R. Clin. Chem., 1991, 37(9):1626-1632
13. [13]
  Marquette C A, Hezard P, Degiuli A, Blum L J. Sens. Actuators B, 2006, 113(2):664-670 doi: 10.1016/j.snb.2005.07.015
14. [14]
  Forster R J, Bertoncello P, Keyes T E. Annu. Rev. Anal. Chem., 2009, 2:359-385 doi: 10.1146/annurev-anchem-060908-155305
15. [15]
  Han M Y, Gao X H, Su J Z, Nie S. Nat. Biotechnol., 2001, 19(7):631-635 doi: 10.1038/90228
16. [16]
  Chattopadhyay P K, Price D A, Harper T F, Betts M R, Yu J, Gostick E, Perfetto S P, Goepfert P, Koup R A, de Rosa S C, Bruchez M P, Roederer M. Nat. Med., 2006, 12(8):972-977 doi: 10.1038/nm1371
17. [17]
  Biju V, Itoh T, Ishikawa M. Chem. Soc. Rev., 2010, 39(8):3031-3056 doi: 10.1039/b926512k
18. [18]
  Wu P, Miao L N, Wang H F, Shao X G, Yan X P. Angew. Chem. Int. Ed., 2011, 50(35):8118-8121 doi: 10.1002/anie.v50.35
19. [19]
  Zhang C, Wu F B, Zhang Y Y, Wang X, Zhang X R. J. Anal. At. Spectrom., 2001, 16(12):1393-1396 doi: 10.1039/b106387c
20. [20]
  Bings N H, Bogaerts A, Broekaert J A C. Anal. Chem., 2010, 82(12):4653-4681 doi: 10.1021/ac1010469
21. [21]
  Zheng C, Yang L, Sturgeon R E, Hou X. Anal. Chem., 2010, 82(9):3899-3904 doi: 10.1021/ac1004376
22. [22]
  Gao Y, Peng X, Shi Z, Zhang R, Xia X, Yue F, Liu R. At. Spectrosc., 2012, 33(3):73-77
23. [23]
  Proefrock D, Prange A. Appl. Spectrosc., 2012, 66(8):843-868 doi: 10.1366/12-06681
24. [24]
  Houk R S, Fassel V A, Flesch G D, Svec H J, Gray A L, Taylor C E. Anal. Chem., 1980, 52(14):2283-2289 doi: 10.1021/ac50064a012
25. [25]
  Bettmer J, Montes Bayon M, Ruiz Encinar J, Fernandez Sanchez M L, del Rosario Fernandez de la Campa M, Sanz Medel A. J. Proteomics, 2009, 72(6):989-1005 doi: 10.1016/j.jprot.2009.05.003
26. [26]
  Adams F C. J. Am. Soc. Mass. Spectrom., 2008, 19(11):R1-2 doi: 10.1016/j.jasms.2008.07.008
27. [27]
  Rodriguez-Gonzalez P, Marchante-Gayon J M, Alonso J I G, Sanz-Medel A. Spectrochim. Acta B, 2005, 60(2):151-207 doi: 10.1016/j.sab.2005.01.005
28. [28]
  PerkinElmer, Inc.2003.The 30-minute guide to ICP-MS. http://www.perkinelmer.com/CMSResources/Images/44-74849tch_icpmsthirtyminuteguide
29. [29]
  Baranov V I, Quinn Z, Bandura D R, Tanner S D. Anal. Chem., 2002, 74(7):1629-1636 doi: 10.1021/ac0110350
30. [30]
  Corthals G L, Wasinger V C, Hochstrasser D F, Sanchez J C. Electrophoresis, 2000, 21(6):1104-1115 doi: 10.1002/(ISSN)1522-2683
31. [31]
  Liu R, Zhang S X, Wei C, Xing Z, Zhang S C, Zhang X R. Acc. Chem. Res., 2016, 49(5):775-783 doi: 10.1021/acs.accounts.5b00509
32. [32]
  Zhang C, Wu F, Zhang X R. J. Anal. At. Spectrom., 2002, 17(10):1304-1307 doi: 10.1039/b205623b
33. [33]
  Zhang C, Zhang Z Y, Yu BB, Shi J J, Zhang X R. Anal. Chem., 2002, 74(1):96-99 doi: 10.1021/ac0103468
34. [34]
  Quinn Z A, Baranov V I, Tanner S D, Wrana J L. J. Anal. At. Spectrom., 2002, 17(8):892-896 doi: 10.1039/b202306g
35. [35]
  Giesen C, Jakubowski N, Panne U, Weller M G. J. Anal. At. Spectrom., 2010, 25(10):1567-1572 doi: 10.1039/c0ja00009d
36. [36]
  Li F, Zhao Q, Wang C, Lu X, Li X F, Le X C. Anal. Chem., 2010, 82(8):3399-3403 doi: 10.1021/ac100325f
37. [37]
  Hu S, Liu R, Zhang S, Huang Z, Xing Z, Zhang X. J. Am. Soc. Mass. Spectrom., 2009, 20(6):1096-1103 doi: 10.1016/j.jasms.2009.02.005
38. [38]
  Liu R, Xing Z, Lv Y, Zhang S, Zhang X. Talanta, 2010, 83(1):48-54 doi: 10.1016/j.talanta.2010.08.037
39. [39]
  Liu R, Liu X, Tang Y, Wu L, Hou X, Lv Y. Anal. Chem., 2011, 83(6):2330-2336 doi: 10.1021/ac103265z
40. [40]
  Liu R, Zhang Y, Zhang S, Qiu W, Gao Y. Appl. Spectrosc. Rev., 2013, 49(2):121-138
41. [41]
  Bustos A R M, Trapiella-Alfonso L, Encinar J R, Costa-Fernandez J M, Pereiro R, Sanz-Medel A. Biosens. Bioelectron., 2012, 33(1):165-171 doi: 10.1016/j.bios.2011.12.046
42. [42]
  Zhang S, Zhang C, Xing Z, Zhang X. Clin. Chem., 2004, 50(7):1214-1221 doi: 10.1373/clinchem.2003.029850
43. [43]
  Hutchinson R W, Ma R L, McLeod C W, Milford-Ward A, Lee D. Can. J. Anal. Sci. Spectros., 2004, 49(6):429-435
44. [44]
  Ornatsky O, Baranov V, Bandura D R, Tanner S D, Dick J. J. Immunol. Methods, 2006, 308(1-2):68-76 doi: 10.1016/j.jim.2005.09.020
45. [45]
  Careri M, Elviri L, Mangia A, Mucchino C. Anal. Bioanal. Chem., 2007, 387(5):1851-1854 doi: 10.1007/s00216-006-1091-0
46. [46]
  Careri M, Elviri L, Maffini M, Mangia A, Mucchino C, Terenghi M. Rapid Commun. Mass Spectrom., 2008, 22(6):807-811 doi: 10.1002/(ISSN)1097-0231
47. [47]
  Ornatsky O I, Baranov V I, Bandura D R, Tanner S D, Dick J. Translational Oncogenomics, 2006, 1:1-9
48. [48]
  Terenghi M, Elviri L, Careri M, Mangia A, Lobinski R. Anal. Chem., 2009, 81(22):9440-9448 doi: 10.1021/ac901853g
49. [49]
  Yan X, Yang L, Wang Q. Angew. Chem. Int. Ed., 2011, 50(22):5130-5133 doi: 10.1002/anie.v50.22
50. [50]
  Lou X, Zhang G, Herrera I, Kinach R, Ornatsky O, Baranov V, Nitz M, Winnik M A. Angew. Chem. Int. Ed., 2007, 46(32):6111-6114 doi: 10.1002/(ISSN)1521-3773
51. [51]
  Bandura D R, Baranov V I, Ornatsky O I, Antonov A, Kinach R, Lou X, Pavlov S, Vorobiev S, Dick J E, Tanner S D. Anal. Chem., 2009, 81(16):6813-6822 doi: 10.1021/ac901049w
52. [52]
  Ornatsky O, Bandura D, Baranov V, Nitz M, Winnik M A, Tanner S. J. Immunol. Methods, 2010, 361(1-2):1-20 doi: 10.1016/j.jim.2010.07.002
53. [53]
  Bendall S C, Simonds E F, Qiu P, Amir E D, Krutzik P O, Finck R, Bruggner R V, Melamed R, Trejo A, Ornatsky O I, Balderas R S, Plevritis S K, Sachs K, Pe'er D, Tanner S D, Nolan G P. Science, 2011, 332(6030):687-696 doi: 10.1126/science.1198704
54. [54]
  Bodenmiller B, Zunder E R, Finck R, Chen T J, Savig E S, Bruggner R V, Simonds E F, Bendall S C, Sachs K, Krutzik P O, Nolan G P. Nat. Biotechnol., 2012, 30(9):858-867 doi: 10.1038/nbt.2317
55. [55]
  Beveridge J S, Stephens J R, Williams M E. Annu. Rev. Anal. Chem., 2011, 4:251-273 doi: 10.1146/annurev-anchem-061010-114041
56. [56]
  Chikkaveeraiah B V, Bhirde A A, Morgan N Y, Eden H S, Chen X. ACS Nano, 2012, 6(8):6546-6561 doi: 10.1021/nn3023969
57. [57]
  Zhao Q, Lu X, Yuan C G, Li X F, Le X C. Anal. Chem., 2009, 81(17):7484-7489 doi: 10.1021/ac900961y
58. [58]
  Cho H K, Lim H B. J. Anal. At. Spectrom., 2013, 28(4):468-472 doi: 10.1039/c3ja30299g
59. [59]
  Chen B, Hu B, Jiang P, He M, Peng H, Zhang X. Analyst., 2011, 136(19):3934-3942 doi: 10.1039/c1an15387k
60. [60]
  Peng H, Chen B, He M, Zhang Y, Hu B. J. Anal. At. Spectrom., 2011, 26(6):1217-1223 doi: 10.1039/c1ja00007a
61. [61]
  Peng H, Jiao Y, Xiao X, Chen B, He M, Liu Z, Zhang X, Hu B. J. Anal. At. Spectrom., 2014, 29(6):1112-1119 doi: 10.1039/c4ja00003j
62. [62]
  Konz T, Anon Alvarez E, Montes-Bayon M, Sanz-Medel A. Anal. Chem., 2013, 85(17):8334-8340 doi: 10.1021/ac401692k
63. [63]
  Zhang Y, Chen B, He M, Yang B, Zhang J, Hu B. Anal. Chem., 2014, 86(16):8082-8089 doi: 10.1021/ac500964s
64. [64]
  Zhang X, Chen B, He M, Wang H, Hu B. Biosens. Bioelectron., 2016, 86:736-740 doi: 10.1016/j.bios.2016.07.073
65. [65]
  Yang B, Chen B, He M, Hu B. Anal. Chem., 2017, 89(3):1879-1886 doi: 10.1021/acs.analchem.6b04314
66. [66]
  Han G, Zhang S, Xing Z, Zhang X. Angew. Chem. Int. Ed., 2013, 52(5):1466-1471 doi: 10.1002/anie.201206903
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