Citation: JIANG Hui, WANG Xue-Mei. Progress of Metal Nanoclusters-based Electrochemiluminescent Analysis[J]. Chinese Journal of Analytical Chemistry, ;2017, 45(12): 1776-1785. doi: 10.11895/j.issn.0253-3820.171292 shu

Progress of Metal Nanoclusters-based Electrochemiluminescent Analysis

JIANG Hui ,
WANG Xue-Mei ^,

School of Biological Science and Medical Engineering, National Demonstration Center for Experimental Biomedical Engineering Education(Southeast University), Southeast University, Nanjing 210096, China

Corresponding author: WANG Xue-Mei, xuewang@seu.edu.cn
Received Date: 3 October 2017
Accepted Date: 27 October 2017

Fund Project: the Natural Science Foundation of Jiangsu Province, China BK20161413This work was supported by the National Natural Science Foundation of China (Nos. 81325011, 21675023), the Natural Science Foundation of Jiangsu Province, China (No. BK20161413), and the Southeast University-Nanjing Medical University Joint Project(No. 2242017K3DN29)the National Natural Science Foundation of China 21675023the Southeast University-Nanjing Medical University Joint Project 2242017K3DN29the National Natural Science Foundation of China 81325011

Figures(7)

In the past ten years, the development of electrochemiluminescent (ECL) analytical methods based on various types of nanostructures has become a research hotspot. Nanocluster, an intermediate between molecules and conventional nanoparticles, is renowned for its luminescent feature. The first report on ECL for nanoclusters can be traced back to 2009. Here we summarized the main research progresses since 2011. Firstly, the preparation of ECL-related nanoclusters was briefly introduced. Then, the mechanisms and applications of ECL by nanoclusters were described. To improve ECL performances, two main strategies, i.e., nanostructure-based ECL enhancement and biological signal amplification were proposed. Besides, the nanoclusters as the energy transfer receptors in ECL systems were also discussed. In prospect part, the future development of ECL by nanoclusters was considered. We believed that the synthesis of high quality nanoclusters, the reveal of ECL structure-activity relationships, the rationale design and application of near-infrared ECL, and the role of ECL in the interdisciplinary research were the main problems we faced in the future.
- Metal nanoclusters,
- Electrochemiluminescence,
- Signal amplification,
- Bioanalysis,
- Review
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